SBIR Phase II: A New Vibration Mixer for Bone Cement

SBIR 第二阶段：新型骨水泥振动搅拌机

• 批准号: 0079484
• 负责人: Pamela Saha
• 金额: $ 39.99万
• 依托单位: Clinical and Industrial Technology Co
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079484&HistoricalAwards=false
• 关键词: SBIR; Phase; II; New; Vibration

This SBIR Phase II project is aimed at developing a novel vibration mixer for the mixing of surgical grade bone cement. Self-curing polymethylmethacrylate (PMMA) or acrylic bone cement is used extensively in total joint replacements, in the repair of bony defects and in the fixation of pathological fractures. For surgical use, the methylmethacrylate polymer and the liquid monomer are hand mixed. This hand-mixing entraps air bubbles making the cement porous. Presence of these bubbles adversely affects the mechanical properties of bone cement, making it much weaker under load and may contribute to early failure of cemented artificial joints. Results of the Phase I study indicate that ultrasonic vibration during cement mixingsignificantly reduced its porosity and increased the fatigue life and mechanical strength of bone cement, compared to hand-mixed cement. Recently, it was shown that combining sonication and vacuum mixing reduced the porosity and further improved the fatigue life, compared to either mixing methods alone.During the Phase II study, the frequency and amplitude of sonication and the vacuum pressure to obtain the best mechanical properties of the cement will be optimized. Subsequently, a new cement mixer will be designed and built incorporating these mixing features. It is expected that the improved mechanical properties of vibrated bone cement will reduce the incidence of cement fracture and this will improve the success rate of total joint replacements. Considering that cement mixers are used in several thousand hospitals in the United States alone, we expect this new cement mixer to be adopted by a large number of Orthopaedic surgeons in these hospitals.

这个SBIR II期项目旨在开发一种新型的振动混合器，用于混合外科级骨水泥。 自固化多甲基丙烯酸酯（PMMA）或丙烯酸骨水泥可广泛用于总关节置换，修复骨缺陷和病理骨折的固定中。 为了手术使用，混合了甲基丙烯酸酯聚合物和液体单体。 这种手工混合扰动气泡使水泥多孔。 这些气泡的存在会不利地影响骨水泥的机械​​性能，使其在负载下弱得多，并可能导致胶结人造关节的早期失败。 第一阶段研究的结果表明，与手工混合水泥相比，水泥混合过程中的超声振动可降低其孔隙率，并提高骨水泥的疲劳寿命和机械强度。 最近，与单独的混合方法相比，将超声处理和真空混合结合起来降低了孔隙率并进一步改善了疲劳寿命。在II期研究，超声处理的频率和振幅和真空压力以获得水泥的最佳机械性能。 随后，将设计和建造一个新的水泥混合器，并结合这些混合功能。 可以预期，振动的骨水泥的机械​​性能的改善将减少水泥骨折的发生率，这将提高关节置换的成功率。 考虑到仅在美国的数千千家医院就使用了水泥搅拌机，我们预计这些新的水泥混合器将被这些医院的大量骨科外科医生采用。