SBIR Phase I: A New Vibration Mixer for Bone Cement

SBIR 第一阶段：新型骨水泥振动搅拌机

• 批准号: 9860470
• 负责人: Pamela Saha
• 金额: $ 9.93万
• 依托单位: Clinical and Industrial Technology Co
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9860470&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Vibration; Mixer

9860470 This Small Business Innovation Research Phase I project is aimed at developing a vibration mixer for the mixing of surgical grade bone cement. Self-curing poly(methyl methacrylate (PMMA) or acrylic bone cement is used extensively in total joint replacements, in the repair of bony defects and in the fixation of pathological fractures. For surgical use, the methylmethacrylate polymer and the liquid monomer are hand mixed. This hand mixing entraps air bubbles making the cement porous. Presence of these bubbles adversely affects the mechanical properties of bone cement, making it much weaker under load. The objective of this project will be: (1) to determine if a similar technique could also be used to reduce the porosity in bone cement; ( 2) to evaluate the resulting improvement in its mechanical properties; and (3 ) to design a vibration apparatus to obtain the maximum improvement in the strength properties of bone cement.. Results of our preliminary study indicate that bone cement in the liquid state, when subjected to ultrasonic vibration, showed increased static compressive and tensile strength, as compared to normal bone cement. During this phase of the project, we plan to optimize the vibration parameters, namely, amplitude and frequency to achieve maximum consolidation and, thus, obtain significantly high strength properties of the bone cement. Subsequently, a mixer with these specifications will be designed in collaboration with a manufacturer of shaker tables and will be marketed for mixing bone cement. Presently centrifuge and vacuum mixed are available for mixing bone cement, but these methods have lost favor with the orthopaedic surgeons. It is expected that the improved mechanical properties of bone cement obtained through the use of a vibration mixer will prolong the long-term survival rate of total joint replacements.

9860470这个小型企业创新研究阶段I项目旨在开发用于混合外科级骨水泥的振动混合器。自固化的聚甲基丙烯酸甲酯（PMMA）或丙烯酸骨水泥被广泛用于总关节置换，修复骨缺损和病理骨折的固定时。用于手术使用，甲基丙烯酸丙烯酸甲酯聚合物和液体单体和液体单体的液体混合的机器人的构成。水泥，使其在负载下要弱。与正常的骨水泥相比，振动显示出静态压缩和拉伸强度的增加。在项目的这一阶段，我们计划优化振动参数，即振幅和频率，以实现最大的巩固，从而获得骨水泥的明显高强度特性。随后，具有这些规格的搅拌机将与摇床桌制造商合作设计，并将被销售用于混合骨水泥。 目前的离心机和真空混合可用于混合骨水泥，但是这些方法对骨科医生失去了青睐。预计通过使用振动混合器获得的骨水泥的机械​​性能的改善将延长总关节置换的长期存活率。