GOALI Project: Comprehensive Model of Molecular Transport and Delivery Through the Skin

GOALI 项目：通过皮肤的分子运输和递送的综合模型

• 批准号: 9818160
• 负责人: Johannes Nitsche
• 金额: $ 19.36万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9818160&HistoricalAwards=false
• 关键词: GOALI; Project; Comprehensive; Model; Molecular

9818160 Nitsche Permeation of molecules through skin is a phenomenon central to the function of drug patches and transdermally delivered drugs, topically applied pharmaceuticals, and a variety of personal cleansing, skin-care and beauty-care products. Better understanding of this process is currently one of themost important factors underlying biomedical advancement and product development in these areas. It is also key to safety issues and the assessment of risks associated with dermal exposure to chemicals and drugs. Strong need therefore exists to be able to predict how, and how fast, different molecules get through the skin. Filling this need requires a basic research effort aimed at understanding the operative transport processes in microscopic detail.The proposed GOALI project will combine academic and industrial resources to develop a comprehensive theoretical model for predicting skin permeability, embodying advances difficult or impossible to achieve within either type of setting individually. It is based on collaboration between a basic academic researcherin the field of microscopic transport phenomena with demonstrated experience in biological applications (Johannes M. Nitsche, State University of New York at Buffalo), and an industrial partner offering uniquely extensive research experience, state-of-the-art experimental capability in skin transport and ultra-structural studies, and strong interest in improved predictive models (Gerald B. Kasting, the Procter & Gamble Company, Miami Valley Laboratories, Cincinnati). The project will produce theory and computational techniques to predict both the basic permeability properties of the epidermal barrier, and the permeability properties of hair follicles and sweat ducts, which penetrate through this surface barrier and provide a shortcut to deeper tissue and the body's circulation. A distinguishing feature of the proposed theory is physical realism, via the incorporation of extensive information and experimental data on tissue structure and material properties at the microscopic scale. This level of realism will ultimately make it possible to predict how fast a given drug or chemical will penetrate through the skin given only its identity (molecular structure) and a specification of how the application or exposure occurs.The permeability model resulting from the proposed project will be relevant in some degree to most transdermal drug delivery systems, topically applied drugs and skin-care products currently in use, under development or under contemplation. It will also be applicable to the risk assessment process for a variety ofchemicals and products that contact the skin.

9818160通过皮肤对分子的渗透是一种现象，是药物斑块和透皮药物功能，局部施用的药品以及各种个人清洁，皮肤护理和美容护理产品的现象。 对这一过程的更好理解是目前在这些领域生物医学进步和产品开发的重要因素之一。 它也是安全问题以及与皮肤接触化学物质和药物相关的风险评估的关键。 因此，存在强大的需求，以预测不同分子从皮肤中进行的速度和速度。 满足这一需求需要一项基础研究工作，旨在了解微观细节中的手术运输过程。拟议的守门员项目将结合学术和工业资源，以开发一种全面的理论模型来预测皮肤渗透性，体现在任何一种类型的设置中难以实现的进步或无法实现的进步。 It is based on collaboration between a basic academic researcherin the field of microscopic transport phenomena with demonstrated experience in biological applications (Johannes M. Nitsche, State University of New York at Buffalo), and an industrial partner offering uniquely extensive research experience, state-of-the-art experimental capability in skin transport and ultra-structural studies, and strong interest in improved predictive models (Gerald B. Kasting, the Procter & Gamble Company,辛辛那提迈阿密谷实验室）。 该项目将产生理论和计算技术，以预测表皮屏障的基本渗透率，以及毛囊和汗水导管的渗透性特性，这些特性通过该表面屏障穿透并为更深的组织和身体的循环提供了快捷方式。 提出的理论的一个区别特征是物理现实主义，通过在微观范围内纳入有关组织结构和材料特性的广泛信息和实验数据。 这种现实主义水平最终将有可能预测给定药物或化学物质仅在皮肤的身份（分子结构）中穿透的速度以及对应用或暴露的发生方式的规范。拟议项目所产生的渗透性模型在某种程度上与当前使用的药物和更易碎的产品相关，在某种程度上与大多数跨多种药物输送系统相关，或者在局部使用，或者以下是相时使用的产品。它也适用于与皮肤接触的各种化学物质和产品的风险评估过程。