GOALI Project: Comprehensive Model of Molecular Transport and Delivery Through the Skin

GOALI 项目：通过皮肤的分子运输和递送的综合模型

• 批准号: 9818160
• 负责人: Johannes Nitsche
• 金额: $ 19.36万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9818160&HistoricalAwards=false
• 关键词: GOALI; Project; Comprehensive; Model; Molecular

9818160 Nitsche Permeation of molecules through skin is a phenomenon central to the function of drug patches and transdermally delivered drugs, topically applied pharmaceuticals, and a variety of personal cleansing, skin-care and beauty-care products. Better understanding of this process is currently one of themost important factors underlying biomedical advancement and product development in these areas. It is also key to safety issues and the assessment of risks associated with dermal exposure to chemicals and drugs. Strong need therefore exists to be able to predict how, and how fast, different molecules get through the skin. Filling this need requires a basic research effort aimed at understanding the operative transport processes in microscopic detail.The proposed GOALI project will combine academic and industrial resources to develop a comprehensive theoretical model for predicting skin permeability, embodying advances difficult or impossible to achieve within either type of setting individually. It is based on collaboration between a basic academic researcherin the field of microscopic transport phenomena with demonstrated experience in biological applications (Johannes M. Nitsche, State University of New York at Buffalo), and an industrial partner offering uniquely extensive research experience, state-of-the-art experimental capability in skin transport and ultra-structural studies, and strong interest in improved predictive models (Gerald B. Kasting, the Procter & Gamble Company, Miami Valley Laboratories, Cincinnati). The project will produce theory and computational techniques to predict both the basic permeability properties of the epidermal barrier, and the permeability properties of hair follicles and sweat ducts, which penetrate through this surface barrier and provide a shortcut to deeper tissue and the body's circulation. A distinguishing feature of the proposed theory is physical realism, via the incorporation of extensive information and experimental data on tissue structure and material properties at the microscopic scale. This level of realism will ultimately make it possible to predict how fast a given drug or chemical will penetrate through the skin given only its identity (molecular structure) and a specification of how the application or exposure occurs.The permeability model resulting from the proposed project will be relevant in some degree to most transdermal drug delivery systems, topically applied drugs and skin-care products currently in use, under development or under contemplation. It will also be applicable to the risk assessment process for a variety ofchemicals and products that contact the skin.

9818160 Nitsche 分子渗透皮肤是药物贴剂和透皮给药药物、局部用药以及各种个人清洁、皮肤护理和美容产品功能的核心现象。 目前，更好地了解这一过程是这些领域生物医学进步和产品开发的最重要因素之一。 它也是安全问题以及与皮肤接触化学品和药物相关风险评估的关键。 因此，强烈需要能够预测不同分子如何以及以多快的速度穿过皮肤。 满足这一需求需要开展基础研究工作，旨在了解微观细节的操作运输过程。拟议的 GOALI 项目将结合学术和工业资源，开发一个用于预测皮肤渗透性的综合理论模型，体现在任何类型中都难以或不可能实现的进步的单独设置。 它基于在生物应用方面具有丰富经验的微观输运现象领域的基础学术研究人员（纽约州立大学布法罗分校的 Johannes M. Nitsche）和提供独特广泛研究经验的工业合作伙伴之间的合作。 - 皮肤传输和超微结构研究方面最先进的实验能力，以及对改进预测模型的浓厚兴趣（Gerald B. Kasting，宝洁公司，迈阿密谷实验室，辛辛那提）。 该项目将产生理论和计算技术来预测表皮屏障的基本渗透性特性，以及毛囊和汗管的渗透性特性，毛囊和汗管穿透这一表面屏障，为更深的组织和身体循环提供捷径。 该理论的一个显着特征是物理现实主义，通过结合微观尺度上组织结构和材料特性的广泛信息和实验数据。 这种真实性水平最终将能够预测给定药物或化学物质渗透皮肤的速度，仅考虑其身份（分子结构）以及应用或暴露如何发生的规范。由拟议项目产生的渗透性模型将在某种程度上与目前使用、正在开发或正在考虑的大多数透皮给药系统、局部应用药物和皮肤护理产品相关。它还适用于各种接触皮肤的化学品和产品的风险评估过程。