U.S.-Japan Cooperative Science: Functional Significance of GnRH Multiplicity in Teleost Fish

美日合作科学：硬骨鱼类 GnRH 多样性的功能意义

• 批准号: 9815869
• 负责人: Yonathan Zohar
• 金额: $ 3.02万
• 依托单位: University of Maryland Biotechnology Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2002-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9815869&HistoricalAwards=false
• 关键词: U.S.; Japan; Cooperative; Science; Functional

9815869ZoharThis award supports a three year collaborative research project between Professor Yohathan Zohar of the University of Maryland Biotechnology Institute and Professor Akihisa Urano of Hokkaido University in Sapporo, Japan. The researchers will be undertaking a study of functional significance of GnRH multiplicity in teleost fish. Gonadotropin releasing hormone (GnRH) is a decapeptide, produced in the brain, which is essential for the control of reproduction in vertebrates. However, it has been discovered that in all vertebrates multiple forms of GnRH coexist in the brain of a single species. This indicates that during evolution GnRHs may have acquired additional functions that are not related to reproduction. The differential roles of the multiple GnRHs are not yet fully understood, and their relative involvement in reproduction has yet to be defined. One of the primary research objectives is to elucidate the relative role each form contributes to the complex process of reproduction. The research is aimed at a detailed study of the physiological significance of the two forms of GnRH present in salmonids, and the three forms present in perciforms. The experimental design includes both an integrative physiologic approach (in vivo studies on intact animals) and a molecular approach (e.g., recombinant GnRH receptor binding assay).This project brings together the efforts of two laboratories that have complementary expertise and research capabilities. The U.S. researchers' expertise is in the area of molecular science and the Japanese have expertise in the physiological area. Results of this research will provide valuable information that can be used by both experimentalists and aquaculturists, and should have an important (and positive) economic impact in providing additional animal protein for human consumption. This research advances international human resources through the participation of a younger scientist and graduate students. Through the exchange of ideas and technology, this project will broaden our base of basic knowledge and promote international understanding and cooperation.***

9815869zoharthis Award支持马里兰大学生物技术学院的Yohathan Zohar教授与日本萨普罗大学北海道大学的Akihisa Urano教授之间的三年合作研究项目。 研究人员将进行一项针对Teleost Fish中GnRH多重性功能意义的研究。 促性腺激素释放激素（GNRH）是在大脑中产生的脱肽，这对于控制脊椎动物的繁殖至关重要。 然而，已经发现，在所有脊椎动物中，单个物种的大脑中有多种形式的GnRH共存。这表明在进化过程中，gnrhs可能已经获得了与繁殖无关的其他功能。 多个GNRH的差异作用尚未完全理解，它们的相对参与尚未定义。 主要的研究目标之一是阐明每种形式的相对作用有助于复杂的繁殖过程。 这项研究针对的是，详细研究了鲑鱼中存在的两种形式的GnRH的生理意义，以及perciforms中存在的三种形式。 实验设计既包括综合生理方法（对完整动物的体内研究）和分子方法（例如，重组GNRH受体结合测定法）。该项目汇集了两个具有互补专业知识和研究能力的实验室的努力。美国研究人员的专业知识是分子科学领域，日本在生理领域具有专业知识。这项研究的结果将提供有价值的信息，这些信息可以由实验家和水产养殖者都可以使用，并且在为人类消费提供额外的动物蛋白方面应该具有重要的（和积极的）经济影响。 这项研究通过年轻的科学家和研究生的参与来推动国际人力资源。 通过思想和技术的交流，该项目将扩大我们的基础知识基础，并促进国际理解与合作。***