NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

NSF/Alfred P. Sloan 基金会 1998 财年分子进化博士后研究奖学金

• 批准号: 9803949
• 负责人: Bonnie McCaig
• 金额: $ 8万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803949&HistoricalAwards=false
• 关键词: NSF; Alfred; P.; Sloan; Foundation

Abstract DBI-9803949 Bonnie C. McCaig This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled evolution of structural components of plants. The lignin in conifers arises from the polymerization of one precursor, whereas that in flowering plants arises from two. The question being addressed is did a second laccase gene family coincide with the origin of syringyl lignin in angiosperms? The two classes of lignin-polymerizing laccases have different substrate preferences, and these classes may be expressed differentially during plant development. This project examines the molecular evolution of genes encoding laccases, the enzymes catalyzing lignin polymerization, to determine whether a separate biosynthetic pathway evolved to supply the syringyl component of angiosperm lignin. Gene phylogenies and expression studies are used to determine whether the classes diverged in parallel with changes in lignin and cell composition during plant evolution.

摘要 DBI-9803949 Bonnie C. McCaig 这项行动资助了 1998 年 NSF/Alfred P. Sloan 分子进化博士后研究奖学金。这些奖学金支持涉及生物模式和过程的理论、比较、计算和/或实验分析的研究。有机体进化变化和适应框架内的分子水平。这些研究还包括使用分子数据来解决更广泛的进化问题。 每项奖学金都支持在赞助实验室中进行的研究和培训计划。 该奖学金的研究和培训计划题为植物结构成分的演化。针叶树中的木质素由一种前体的聚合产生，而开花植物中的木质素由两种前体聚合产生。正在解决的问题是第二个漆酶基因家族是否与被子植物中紫丁香基木质素的起源一致？两类木质素聚合漆酶具有不同的底物偏好，并且这些类别在植物发育过程中可能有差异表达。该项目检查编码漆酶（催化木质素聚合的酶）的基因的分子进化，以确定是否进化出单独的生物合成途径来提供被子植物木质素的紫丁香基成分。基因系统发育和表达研究用于确定植物进化过程中类别的分化是否与木质素和细胞组成的变化同时发生。