NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

NSF/Alfred P. Sloan 基金会 1998 财年分子进化博士后研究奖学金

• 批准号: 9803938
• 负责人: Dawn Field
• 金额: $ 8万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803938&HistoricalAwards=false
• 关键词: NSF; Alfred; P.; Sloan; Foundation

Abstract DBI-9803938 Dawn Field This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled adaptive molecular evolution of a bacterial pathogen. Thirteen mutable repeats (microsatellites) are embedded within virulence factors in Haemophilus. influenzae. This study tests the hypothesis that genetic variability at these repeats is an important factor in determining the evolutionary success of individual isolates of this bacterium. One hundred twenty epidemiologically diverse strains of H. influenzae are being genotyped, and rates of mutation determined.

摘要 DBI-9803938 Dawn Field 这项行动资助了 1998 年 NSF/Alfred P. Sloan 分子进化博士后研究奖学金。这些奖学金支持涉及分子进化生物学模式和过程的理论、比较、计算和/或实验分析的研究。有机体进化变化和适应框架内的水平。 这些研究还包括使用分子数据来解决更广泛的进化问题。 每项奖学金都支持在赞助实验室中进行的研究和培训计划。 该奖学金的研究和培训计划题为细菌病原体的适应性分子进化。 嗜血杆菌的毒力因子中嵌入了十三个可变重复序列（微卫星）。流感。这项研究检验了这样的假设：这些重复的遗传变异是决定该细菌个体分离株进化成功的重要因素。 正在对一百二十种流行病学上不同的流感嗜血杆菌菌株进行基因分型，并确定突变率。