NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

NSF/Alfred P. Sloan 基金会 1998 财年分子进化博士后研究奖学金

• 批准号: 9803890
• 负责人: Timothy Heuer
• 金额: $ 8万
• 依托单位: Fellowships
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803890&HistoricalAwards=false
• 关键词: NSF; Alfred; P.; Sloan; Foundation

Abstract DBI-9803890 Timothy S. Heuer This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled selection of protein molecules that bind biologically important small molecules: a study of functional and structural protein diversity and evolution. Peptides that bind biologically important molecules (e.g. ATP, glutathione) will be selected from a library of 1013 random sequence molecules. Enrichment of functional peptides occurs by binding the target ligand and selectively amplifying the encoding mRNA, covalently attached during in vitro translation. After many rounds of selection and amplification, emergent peptides will be characterized and compared to natural motifs.

摘要 DBI-9803890 Timothy S. Heuer 这项行动资助了 1998 年 NSF/Alfred P. Sloan 分子进化博士后研究奖学金。这些奖学金支持涉及生物模式和过程的理论、比较、计算和/或实验分析的研究。有机体进化变化和适应框架内的分子水平。 这些研究还包括使用分子数据来解决更广泛的进化问题。 每项奖学金都支持在赞助实验室中进行的研究和培训计划。 该奖学金的研究和培训计划的标题是结合生物学上重要的小分子的蛋白质分子的选择：功能和结构蛋白质多样性和进化的研究。 将从 1013 个随机序列分子的库中选择结合生物学重要分子（例如 ATP、谷胱甘肽）的肽。功能性肽的富集是通过结合靶配体并选择性扩增在体外翻译过程中共价连接的编码 mRNA 来实现的。经过多轮选择和扩增后，将对新出现的肽进行表征并与天然基序进行比较。