Acquisition of Wide Bore Nuclear Magnetic Resonance Imager

获取大口径核磁共​​振成像仪

• 批准号: 9601691
• 负责人: James Glazier
• 金额: $ 43.5万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-11-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9601691&HistoricalAwards=false
• 关键词: Acquisition; Wide; Bore; Nuclear; Magnetic

9601691 Glazier The University of Notre Dame will purchase a Magnetic Resonance Imaging (MRI) to pursue research in the department of Biological Sciences, Chemistry and Biochemistry, Chemical Engineering, Electrical Engineering and Physics. Research problems include the study of the evolution of foams, their structures and the time dependence of their rheology; the flow of liquids including foams in porous media; the imaging of flow in concentrated suspensions and their properties; the architecture of neural network as a source of information for the mathematical modeling of these networks; hibernating myocardium and fumarate reductase as a study of anaerobiosis and metabolic alteration; the design of selective MRI contrast agents and studies of tissue freezing and cryoprotectant distribution as a metabolic response. The results obtained from these studies will support the research of the OLISAO program in the Department of Electrical Engineering which develops theory and numerical simulations to fit and process image signals. These studies vary from theoretical to applied and form engineering design to neurobiology. The support from LISA will aid in developing improved imaging technology and increase speed and accuracy in processing of data into images. The proposed studies either require static imaging of prepared samples or study of the changes of images in time. These projects can all be adequately performed with a vertical, high resolution NMR imagine spectrometer operating at 300 MHz (7 Tesla magnetic field) with the necessary accessories to acquire and process data. The in-vivo probe (64mm working diameter) will monitor 1H at gradient strengths of 20 G/cm (at 40 A), suitable for high resolution 3-d imaging experiments on frog and for large scale hydrodynamics experiments. The microimaging probe will be available with 0.4 cm to 2.5 cm coils for various nuclei, with microprobes for microimaging at a resolution below 100 um for use in high resolution materials science and bioc hemistry experiments. Some of the hardware and software will require custom design for individual experiments. Three NMR specialists will be present in the NMR facility, one devoted solely to MRI and one with extensive MRI experience, to provide support for experiment development and execution. The current proposal includes 10 faculty, 5 postdoctoral, 12 graduate students and 5 undergraduate researchers. MRI will also be used in undergraduate courses with an enrollment of about 65 and graduate courses with an annual enrollment of about 25. ***

9601691 Glazier Notre Dame大学将购买磁共振成像（MRI），以在生物科学，化学和生物化学，化学工程，电气工程和物理学的生物科学系进行研究。 研究问题包括研究泡沫的演变，它们的结构以及其流变学的时间依赖性； 液体在多孔培养基中的流动；集中悬浮液及其特性中的流量成像；神经网络的体系结构是这些网络数学建模的信息来源；冬眠心肌和富马酸盐还原酶作为厌氧菌和代谢改变的研究；选择性MRI对比剂的设计以及组织冷冻和冷冻保护剂分布作为代谢反应的研究。 从这些研究中获得的结果将支持电气工程系Olisao计划的研究，该计划开发了理论和数值模拟以适应和处理图像信号。 这些研究从理论到应用和形成工程设计到神经生物学都不同。 丽莎的支持将有助于开发改进的成像技术，并提高数据处理数据中的速度和准确性。 拟议的研究要么需要静态样品的静态成像，要么需要及时研究图像的变化。 这些项目都可以通过垂直，高分辨率的NMR想象光谱仪在300 MHz（7 Tesla磁场）上进行的垂直，高分辨率NMR进行充分执行，并具有获得和处理数据的必要配件。 体内探针（64mm工作直径）将以20 g/cm的梯度强度（在40 A处）监测1H，适用于青蛙和大规模流体动力学实验的高分辨率3-D成像实验。 各种核的微型成像探针将以0.4 cm至2.5 cm的线圈提供，微型探针以低于100 UM的分辨率进行微型探针，以用于高分辨率材料科学和生物疗法实验。 一些硬件和软件将需要自定义设计进行单个实验。 NMR的三名专家将出现在NMR设施中，其中一个专门专门专门用于MRI，其中一位具有丰富的MRI经验，以提供对实验开发和执行的支持。 当前的建议包括10名教职员工，5名博士后，12名研究生和5名本科研究人员。 MRI还将在本科课程中使用，约有65份和研究生课程，年度入学率约为25。***