Collaborative Research: Improving Post-Translational Processing in Baculovirus Expression System

合作研究：改善杆状病毒表达系统的翻译后处理

• 批准号: 9412249
• 负责人: Michael Shuler
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9412249&HistoricalAwards=false
• 关键词: Collaborative; Research; Improving; Post; Translational

9412249 Shuler This project is on research to improve protein production and processing in insect cells through four goals: (1) the design of cells that are more capable of complete processing; (2) the development of improved media which mimics in vivo conditions; (3) the determination of cell culture conditions that alter intracellular protein processing; and (4) the development of improved expression vectors. This research could produce more efficient methods to produce therapeutic proteins.

9412249 Shuler 该项目旨在通过四个目标来改善昆虫细胞中的蛋白质生产和加工：（1）设计更有能力完成加工的细胞； (2) 开发模拟体内条件的改良培养基； (3) 确定改变细胞内蛋白质加工的细胞培养条件； (4)改进表达载体的开发。 这项研究可以产生更有效的方法来生产治疗性蛋白质。