RPG: Regulation of Neurogenesis Throughout the Lifespan

RPG：整个生命周期神经发生的调节

• 批准号: 9408170
• 负责人: Susan Brown
• 金额: $ 1.79万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9408170&HistoricalAwards=false
• 关键词: RPG; Regulation; Neurogenesis; Throughout; Lifespan

9408170 Brown ABSTRACT The long-term objectives of this project are to understand how new brain cells can be added to adult brains. In mammals including humans, brain cells called neurons are created only during very early development, and neurons that are lost as a result of injury or disease cannot be replaced. Using an animal model in which neurons are added to already-existing brain circuits which are important for learning and producing sounds used to communicate, anatomical and behavioral studies will address the biological events that promote the addition of new neurons to the brain. Understanding how neurons may be added to the brain could lead to therapies which would ameliorate the devastating effects of neurological disease.

9408170棕色摘要该项目的长期目标是了解如何将新的脑细胞添加到成年大脑中。 在包括人类在内的哺乳动物中，只有在非常早期发育过程中就产生了称为神经元的脑细胞，而因受伤或疾病而失去的神经元无法替代。 使用一种动物模型，将神经元添加到已经存在的脑电路中，对于学习和产生用于交流的声音很重要的动物模型，解剖学和行为研究将解决促进向大脑增加新神经元的生物学事件。 了解如何将神经元添加到大脑中可能导致疗法，从而改善神经系统疾病的毁灭性作用。