New Approaches for Selectivity and Atom Efficiency in the Synthesis of Organic Compounds

有机化合物合成中选择性和原子效率的新方法

• 批准号: 9122761
• 负责人: Barry Trost
• 金额: $ 93.42万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9122761&HistoricalAwards=false
• 关键词: New; Approaches; Selectivity; Atom; Efficiency

The focus of this research is the synthetic potential inherent in catalysis by transition metal complexes. Allyl systems involving Pd, Mo, Ni and W will be manipulated to obtain chemo-, regio-, diastereo-, and enantioselective transformations. Among the other topics to be investigated in the project are: Intramolecular carbametallation, metal catalyzed proton shifts leading to reactive intermediates that can undergo prototropic cycloisomerization, bifunctional reagents including organosulfur intermediates, and the design of composite functional groups. The theme of developing reactions that minimize chemical waste pervades every aspect ofthe work. %%% With this Accomplishment Based Renewal award, the Synthetic Organic Program is supporting the research of Dr. Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost will focus his work on developing efficient synthetic approaches to complex organic molecules of theoretical and biological interest while increasing "atom economy". The use of catalytic amounts of transition metal complexes is stressed in the work.

这项研究的重点是过渡金属配合物催化中固有的合成潜力。 涉及 Pd、Mo、Ni 和 W 的烯丙基系统将被操纵以获得化学选择性、区域选择性、非对映选择性和对映选择性转化。 该项目要研究的其他主题包括：分子内碳金属化、金属催化质子转移产生可进行质子环异构化的反应性中间体、包括有机硫中间体在内的双功能试剂，以及复合官能团的设计。 开发最大限度减少化学废物的反应这一主题贯穿了工作的各个方面。 %%% 通过这项基于成就的续订奖，合成有机项目正在支持斯坦福大学化学系的 Barry M. Trost 博士的研究。 Trost 教授的工作重点是开发具有理论和生物学意义的复杂有机分子的有效合成方法，同时提高“原子经济性”。 该工作强调了催化量的过渡金属配合物的使用。