New Approaches for Efficiency in the Synthesis of Organic Compounds

提高有机化合物合成效率的新方法

• 批准号: 9501472
• 负责人: Barry Trost
• 金额: $ 184.74万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9501472&HistoricalAwards=false
• 关键词: New; Approaches; Efficiency; Synthesis; Organic

The focus of this research is to expand the basic set of chemical reactions available to the organic chemist for application to the synthesis of complex molecules. There are five areas of concentration. The first is the development of addition reactions based upon the excellent coordination chemistry of acetylenes with transition metals. In this context, new classes of cycloaddition reactions will emerge which build molecular complexity rapidly. The second area involves allylpalladium chemistry whereby a series of modularly designed ligands controls absolute stereochemistry or chirality. The third area involves the ability of silicon to promote carbon-carbon bond formation. The fourth area probes the development of phosphines as novel catalysts. Finally, the fifth area builds upon the versatility of sulfur to impart unusual reactivity, especially in sulfones and sulfenium ions. With this award, the Synthetic Organic Program is supporting the research of Dr. Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost will focus his work on developing efficient synthetic methodology which is applicable to approaches to complex organic molecules of theoretical and biological interest. The use of organometallic intermediates, both catlytic and stoichiometric, is stressed in the work.

这项研究的重点是扩展有机化学家可用的基本化学反应集，以应用于复杂分子的合成。有五个重点领域。 第一个是基于乙炔与过渡金属的优异配位化学的加成反应的发展。在这种背景下，新型环加成反应将会出现，它们会迅速增加分子的复杂性。第二个领域涉及烯丙基钯化学，其中一系列模块化设计的配体控制绝对立体化学或手性。第三个领域涉及硅促进碳-碳键形成的能力。第四个领域探讨膦作为新型催化剂的开发。 最后，第五个领域以硫的多功能性为基础，赋予其不同寻常的反应活性，特别是在砜和硫鎓离子中。凭借该奖项，合成有机项目将支持斯坦福大学化学系 Barry M. Trost 博士的研究。 Trost 教授的工作重点是开发有效的合成方法，该方法适用于具有理论和生物学意义的复杂有机分子的方法。该工作强调了催化和化学计量的有机金属中间体的使用。