Synaptic Physiology in the Isolated Mammalian Cochlea

离体哺乳动物耳蜗的突触生理学

• 批准号: 9114245
• 负责人: Jonathan Siegel
• 金额: $ 2.36万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9114245&HistoricalAwards=false
• 关键词: Synaptic; Physiology; Isolated; Mammalian; Cochlea

The cochlea is the receptor organ for hearing in mammals. One group of its mechanosensory cells, the inner hair cells, make unique functional synaptic contacts with auditory sensory neurons that carry information to the brain. Unlike many other synaptic sites, in the mammalian cochlea a single active zone of one inner hair cell usually constitutes the entire synaptic input to the afferent neurons, unlike the extensive branching common elsewhere. This exploratory project will develop a novel isolated preparation of the mammalian cochlea to exploit the unique opportunity to study the physiology of a single synaptic active zone. Results will be important to our understanding of synaptic mechanisms, and the isolated preparation will provide an important new approach with impact on auditory neuroscience.

耳蜗是用于哺乳动物的受体器官。 它的一组机械感力细胞（内毛细胞）与带有信息的听觉感觉神经元与大脑的听觉感觉神经元建立了独特的功能突触接触。 与许多其他突触部位不同，在哺乳动物的耳蜗中，一个内部毛细胞的单个活动区通常构成传入神经元的整个突触输入，这与其他地方的广泛分支不同。 这个探索性项目将开发出哺乳动物耳蜗的新型孤立制备，以利用研究单个突触活动区的生理学的独特机会。 结果对于我们对突触机制的理解至关重要，孤立的制剂将为您提供一种重要的新方法，并影响听觉神经科学。