Gas Chromatography-Mass Spectrometry in Undergraduate Chemistry Instruction

气相色谱-质谱法在本科化学教学中的应用

• 批准号: 9051169
• 负责人: Bert Holmes
• 金额: $ 3.19万
• 依托单位: Lyon College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9051169&HistoricalAwards=false
• 关键词: Gas; Chromatography; Mass; Spectrometry; Undergraduate

Through this project, the institution was able to purchase a gas chromatograph/mass spectrometer. A central theme is the improvement of students' understanding of reaction mechanisms and stereochemistry. In the first semester Organic Chemistry, GC/MS helped to introduce the concept of carbocation stability. In the second semester, GC/MS was used to analyze the stereochemistry of addition reactions that form threo- or erythro-bromo- deuteriobutane and the subsequent base-promoted elimination reactions of these stereoisomers. Such difficult concepts are seldom addressed in conventional organic laboratory due to the lack of proper instrumentation. In Physical Chemistry the GC/MS is being used to determine kinetic isotope effects and stereochemistry for gas-phase syn-elimination of the previously prepared deuterated bromobutanes. The Instrumental Chemistry course is emphasizing technique, operation of the instrument, its capabilities and interpretation of spectra. In Environmental Chemistry GC/MS is helping demonstrate detection and quantification of organic contaminants in ground water. Many students find the GC/MS vital to their undergraduate research projects. Through more sophisticated experiments the GC/MS is improving instruction in Organic, Physical, Instrumental, and Environmental Chemistry courses. The institution contributed to this project in an amount equal to the NSF funds.

通过该项目，该机构能够购买气相色谱/质谱仪。 一个中心主题是对学生对反应机制和立体化学的理解的了解。 在第一学期的有机化学中，GC/MS有助于介绍碳分配稳定性的概念。 在第二学期中，GC/MS用于分析形成三或红外溴化丁烷的添加反应的立体化学，以及随后对这些立体异构体的基础促进的消除反应。 由于缺乏适当的仪器，这种困难的概念很少在常规有机实验室中得到解决。 在物理化学中，GC/MS用于确定先前准备好的氘化溴化烷的气相同位素的动力学效应和立体化学。 乐器化学课程强调了技术，仪器的运作，其功能和光谱的解释。 在环境化学中，GC/MS有助于证明地下水中有机污染物的检测和定量。 许多学生发现其本科研究项目的GC/MS至关重要。 通过更复杂的实验，GC/MS正在改善有机，物理，工具和环境化学课程的指导。 该机构以等于NSF资金的数量为该项目做出了贡献。