Improving Social Decisions Concerning Potentially Carcinogenic Chemicals

改善有关潜在致癌化学品的社会决策

• 批准号: 8922017
• 负责人: Lester Lave
• 金额: $ 9.21万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8922017&HistoricalAwards=false
• 关键词: Improving; Social; Decisions; Concerning; Potentially

This proposal outlines a significant project to evaluate a quantitative approach to carcinogenic screening. The scientific foundation for testing potentially carcinogenic chemicals is in a state of controversy. Regulatory agencies must formulate policies for testing and interpreting bioassay results with a goal of lowing the incidence of cancer without needlessly penalizing the economy. The principal investigators have developed models to measure the information value of bioassays. They propose to extend the models and demonstrate how they can improve current regulatory decisions. The proposed research provides a structure for scientific thinking about uncertainty in testing potentially carcinogenic chemicals. This project has considerable potential for helping federal and state regulators, as well as chemical manufacturers, to make better decisions. In all, the anticipated impact of the research fully justifies support for the proposal.

该提案概述了评估致癌筛查的定量方法的重要项目。 测试潜在致癌化学物质的科学基础处于争议状态。 监管机构必须制定测试和解释生物测定结果的政策，目的是降低癌症的发病率，而不必惩罚经济。 主要研究人员已经开发了衡量生物测定信息价值的模型。 他们建议扩展模型并证明如何改善当前的监管决策。 拟议的研究为测试潜在致癌化学物质的不确定性的科学思考提供了一种结构。 该项目具有帮助联邦和州监管机构以及化学制造商做出更好决定的巨大潜力。 总的来说，研究的预期影响完全证明了对该提案的支持。