Improving the stability of biomolecules using ionic liquids

使用离子液体提高生物分子的稳定性

• 批准号: DP230101712
• 负责人: Prof Tamar Greaves
• 金额: $ 30.97万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101712
• 关键词: Improving; stability; biomolecules; using; ionic

This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set of design rules for creating new solvents. This should benefit many research and industrial applications, including determining protein structure for the development of new drugs and biocatalysts, and cryopreservation of protein-based pharmaceuticals.

该项目旨在通过开发可提高蛋白质稳定性和溶解度的新溶剂来解决在天然环境之外研究蛋白质的关键问题。该项目期望通过使用高通量机器人技术、同步加速器分析蛋白质结构和分子动力学模拟的新方法，为我们理解溶剂化学性质创造新的知识。预期结果是一套用于创造新溶剂的设计规则。这应该有利于许多研究和工业应用，包括确定用于开发新药和生物催化剂的蛋白质结构，以及基于蛋白质的药物的冷冻保存。