MRI: Development of Peptidergic Cells in the SympathoadrenalSystem

MRI：交感肾上腺系统肽能细胞的发育

• 批准号: 8801538
• 负责人: Jose Garcia-Arraras
• 金额: $ 24.73万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8801538&HistoricalAwards=false
• 关键词: MRI; Development; Peptidergic; Cells; SympathoadrenalSystem

The peripheral nervous system is formed, almost in its entirety by neural crest cells that migrate and associate in specific areas of the developing embryo. During the process of gangliogenesis these cells acquire particular traits and eventually differentiate into the various phenotypes found in the adult. The aims of this research are: (1) to document the development of peptidergic phenotypes in the sympathoadrenal branch of the peripheral nervous system, from neural crest cells to the terminally differentiated state found in the chicken and quail adult and (2) to examine the influence of extrinsic factors on peptidergic expression by culturing neural crest cells and dissociated embryonic ganglion cells in the presence of conditioned media, cell free extracts, or hormones, and other factors likely to be encountered by developing crest cells. Results from this project will provide a precise map of the peptidergic cell populations in the developing peripheral nervous system and the time course of their appearance. They will also define the contribution of environmental mechanisms to the induction and maintenance of peptidergic phenotypes. In addition, these results will provide basic embryological information that could aid considerably our understanding of the mechanisms underlying the development and plasticity of peripheral nervous system.

周围神经系统是形成的，几乎是由神经rest细胞整体形成的，这些细胞在发育中的胚胎的特定区域中迁移并关联。 在神经节发生的过程中，这些细胞获得了特定的性状，并最终分化为成年人中发现的各种表型。 这项研究的目的是：（1）记录周围神经系统交感神经肾上腺分支中肽盖表型的发展，从神经crest细胞到鸡肉和鹌鹑成人中发现的终端分化状态，以及（2），以检查肽培养型细胞和跨性别细胞的影响，从激素和其他因素可能会通过发展冠细胞而遇到。 该项目的结果将为发育中的周围神经系统和外观的时间过程提供精确的图表。 他们还将定义环境机制对肽能表型的诱导和维持的贡献。 此外，这些结果将提供基本的胚胎学信息，这些信息可以大大帮助我们理解周围神经系统发展和可塑性的基础机制。