Pharmacogenomics of human UDP-glucuronosyltransferases: From single genetic polymorphisms to a complex regulation of enzyme activity.

人类 UDP-葡萄糖醛酸基转移酶的药物基因组学：从单一遗传多态性到酶活性的复杂调节。

• 批准号: 171323
• 负责人: Guillemette Chantal
• 金额: $ 59.04万
• 依托单位: Centre hospitalier de l'Universit Laval (Qubec)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=171323&lang=en
• 关键词: Drug Metabolism; Phase Ii; Udp-Glucuronosyltransferases

Glucuronosyltransferase (UGT) enzymes are responsible for the glucuronidation metabolic pathway and play an essential role in the elimination and detoxification of a large diversity of drugs from all classes, accounting for ~35% of drug conjugation. In hu

葡萄糖醛酸转移酶 (UGT) 负责葡萄糖醛酸化代谢途径，并在各类药物的消除和解毒中发挥重要作用，约占药物结合的 35%。在胡