大气细颗粒物的毒理与健康效应战略研究

The Major Research Plan of Natural Science Foundation of China “Toxicology and Health Effects of Atmospheric Fine Particulate Matters” has been implemented in five research directions, including 1) source, evolution and identification of toxic components in atmospheric fine particulate matters, 2) exposome study of atmospheric fine particulate matters, 3) interaction and toxicity mechanism of fine particulate matter components and biomolecules, 4) epidemiological study on health hazards of people exposed to atmospheric fine particulate matters, and 5) health hazard mechanisms of toxic components in atmospheric fine particulate matters. The Major Research Plan has made original achievements in the traceability technology of PM2.5, epidemiological research and population intervention, and has been rated as excellent in the mid-term assessment in 2019. Based on the implementation status of the Major Research Plan, we hereby propose a strategic research project, which will be executed to better organize and implement the research of “Toxicology and Health Effects of Atmospheric Fine Particulate Matters”, further strengthen the summary, publicity and publication of the achievements, and guarantee the complement of expected goals.

“大气细颗粒物的毒理与健康效应”重大研究计划围绕大气细颗粒物毒性组分的来源、演化与甄别、大气细颗粒物的暴露组学、细颗粒物组分与生物分子的交互作用及毒性机理、大气细颗粒物污染人群健康危害的流行病学研究和大气细颗粒物毒性组分的健康危害机制五个研究方向，在PM2.5溯源技术、流行病研究和人群干预等方面取得了若干原创性成果，并在2019年的中期评估中获得优秀。根据整个计划的执行情况，为了更好的组织和实施“大气细颗粒物的毒理与健康效应”研究，进一步加强对已取得成果的总结、宣传和出版，顺利完成预期目标，特提出此战略研究项目。

“大气细颗粒物的毒理与健康效应”重大研究计划已执行8年，近百个研究项目得到资助，在PM2.5的毒性组分辨识与溯源、环境流行病学证据和特征、污染的典型健康危害等方面取得重要突破。本项目期间完成对3项集成项目和4项重点资助项目的总结评审。然而，关于PM2.5健康危害的全链条证据尚不完整，对PM2.5健康危害的认识的科学理论仍有待提升。因此，未来需充分总结开展项目的研究成果，对PM2.5健康危害形成完整证据链，形成并提升PM2.5毒理与健康效应的科学理论。此外，重大研究计划还需进一步加强对已取得成果的总结、宣传和出版。

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