Alternative splicing of Grin1 controls NMDA receptor function in physiological and disease processes

Grin1 的选择性剪接控制生理和疾病过程中的 NMDA 受体功能

• 批准号: 488788
• 负责人: Salter Michael W
• 金额: $ 83.04万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2028-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=488788&lang=en
• 关键词: Electrophysiology; Glutamate Receptors; Neuroscience; Nmda Receptors; Non-Ionotropic Signaling; Receptor Subunit Splice Variants; Synaptic Plasticity

Communication between neurons in the brain and spinal cord is mainly mediated by the excitatory amino acid neurotransmitter glutamate. Glutamate therefore is key to a wide range of normal processes such as sensation, perception, learning and memory, and t

大脑和脊髓中神经元之间的通讯主要由兴奋性氨基酸神经递质谷氨酸介导。因此，谷氨酸对于感觉、知觉、学习和记忆等一系列正常过程至关重要。