Defining the role of monocytes in protective immunity against healing and non-healing Leishmaniasis: implications for treatment and vaccination against phagosomal pathogens.

定义单核细胞在针对愈合和非愈合利什曼病的保护性免疫中的作用：对吞噬体病原体的治疗和疫苗接种的影响。

• 批准号: 495111
• 负责人: Peters Nathan
• 金额: $ 7.29万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=495111&lang=en
• 关键词: Clinical Isolates; Intracellular Pathogens; Leishmania; Monocytes; Non-Healing Disease; Phagosomal Infections; T Cells; Tnfr Superfamily; Vaccination

The objective of this grant is to gain a better understanding of the mechanisms of infected cell activation in settings of pre-existing T helper 1 (Th1)/Cell-mediated immunity (prior infection, vaccination) against phagosomal infections. Specifically the

这笔资助的目的是更好地了解在预先存在的 T 辅助细胞 1 (Th1)/细胞介导的免疫（感染前、疫苗接种）环境中针对吞噬体感染的受感染细胞激活机制。具体来说