Research Training on Intracellular Pathogens

细胞内病原体研究培训

• 批准号: 7799830
• 负责人: KENNETH D STUART
• 金额: $ 18.71万
• 依托单位: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-20 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7799830
• 关键词: Area; Bioinformatics; Collaborations; Communicable Diseases; Country; Development; Disease; Educational workshop; Enrollment; Ethics; Faculty; Genetic Engineering; Genus Mycobacterium; Immunocompromised Host; India; Institution; International; Laboratories; Leishmania; Leishmaniasis; Malaria; Plasmodium; Research; Research Personnel; Research Project Grants; Research Training; Risk; Students; Training; Training Programs; Tuberculosis; Universities; Visceral; Visit; Work; base; design; experience; international center; pathogen; programs

DESCRIPTION (provided by applicant): This research-training program will be conducted in the context of international collaborations and is designed to provide training for international trainees who are in graduate degree programs, for postdoctorates and for faculty researchers in India, primarily at Jawaharlal Nehru University (JNU) in New Delhi. The program is designed to provide training, stimulate collaboration between JNU and SBRI/UW researchers, and provide research strengthening for JNU and its interacting Indian research institutions, particularly the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi. The training program will be conducted in association with research projects on infectious diseases of global importance and which are of critical importance to India. The training will emphasize research training on intracelluar pathogens with a focus on the Leishmania, Plasmodium, and Mycobacterium. These emphases have been chosen because of the problems of leishmaniasis (especially visceral disease), malaria, and tuberculosis in India are worsening for a variety of reasons and since Leishmania and TB are opportunists, putting immunocompromised patients at risk. Training will highlight the combination of laboratory experimentation and bioinformatics and will build on established JNU SBRI/UW research collaborations and stimulate the development of new ones. The training will include in-country workshops on alternate years that have been so successful in the past. These will include laboratory and didactic training and provide a part of the basis for selecting trainees for a research training experience in Seattle. Seattle-based training will provide for a portion of graduate degree program research requirements for student trainees who are enrolled in graduate degree programs at JNU or at the UW. Training will also be available in Seattle for Indian postdoctorals participating in international collaborations and for short working visits of collaborating JNU faculty. The training will also provide opportunities for interactions among trainees from various international training programs (especially FIC supported) and include training in areas of importance that is common to these programs such as regulatory and ethical aspects. The Indian partner institution will be JNU to stimulate additional research collaborations and to take advantage of its working linkages with other key Indian research institutions such as ICGEB.

描述（由申请人提供）：该研究培训计划将在国际合作的背景下进行，旨在为印度研究生学位课程的国际学员、博士后和教职研究人员提供培训，主要在贾瓦哈拉尔尼赫鲁新德里大学（JNU）。该项目旨在提供培训，促进暨南大学和 SBRI/UW 研究人员之间的合作，并为暨南大学及其互动的印度研究机构，特别是位于新德里的国际遗传工程和生物技术中心 (ICGEB) 提供研究加强。该培训计划将与具有全球重要性且对印度至关重要的传染病研究项目结合进行。培训将强调细胞内病原体的研究培训，重点是利什曼原虫、疟原虫和分枝杆菌。选择这些重点是因为印度的利什曼病（特别是内脏疾病）、疟疾和结核病问题由于各种原因正在恶化，而且利什曼原虫和结核病是机会主义者，使免疫功能低下的患者处于危险之中。培训将强调实验室实验和生物信息学的结合，并将建立在暨南大学SBRI/UW研究合作的基础上，并刺激新合作的发展。培训将包括关于隔年的国内研讨会，这些研讨会在过去非常成功。这些将包括实验室和教学培训，并为选择在西雅图进行研究培训的学员提供部分基础。西雅图的培训将为在暨南大学或华盛顿大学研究生学位课程注册的学员提供部分研究生学位课程研究要求。还将在西雅图为参与国际合作的印度博士后以及暨南大学合作教师的短期工作访问提供培训。培训还将为来自各种国际培训计划（特别是 FIC 支持的）的学员提供互动的机会，并包括这些计划共同的重要领域的培训，例如监管和道德方面。印度合作机构将是暨南大学，以促进更多的研究合作，并利用其与 ICGEB 等其他印度主要研究机构的工作联系。

项目成果

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.

蛋白质复合物指导恶性疟原虫中血红蛋白到疟原虫色素的形成。

• 发表时间: 2013-04-02
• 影响因子: 11.1
• 作者: Chugh, Monika;Sundararaman, Vidhya;Kumar, Saravanan;Reddy, Vanga S;Siddiqui, Waseem A;Stuart, Kenneth D;Malhotra, Pawan
• 通讯作者: Malhotra, Pawan

Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.

分子证据表明，与短效氯丙胍/氨苯砜相比，长效抗叶酸药物乙胺嘧啶/磺胺多辛对肯尼亚恶性疟原虫产生更大的耐药性选择压力。

• 发表时间: 2000-06
• 作者: Nzila, A M;Nduati, E;Mberu, E K;Hopkins Sibley, C;Monks, S A;Winstanley, P A;Watkins, W M
• 通讯作者: Watkins, W M

Proteolytic activity of Plasmodium falciparum subtilisin-like protease 3 on parasite profilin, a multifunctional protein.

恶性疟原虫枯草杆菌蛋白酶 3 对寄生虫 profilin（一种多功能蛋白）的蛋白水解活性。

• 发表时间: 2013-10
• 影响因子: 1.5
• 作者: Alam, Asrar;Bhatnagar, Raj K;Relan, Udbhav;Mukherjee, Paushali;Chauhan, Virander S
• 通讯作者: Chauhan, Virander S

Paromomycin: uptake and resistance in Leishmania donovani.

巴龙霉素：杜氏利什曼原虫的摄取和耐药性。

• 发表时间: 2009-04
• 影响因子: 1.5
• 作者: Jhingran, Anupam;Chawla, Bhavna;Saxena, Shailendra;Barrett, Michael Peter;Madhubala, Rentala
• 通讯作者: Madhubala, Rentala

High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric beta-lactamase assay.

使用比色 β-内酰胺酶测定对杜氏利什曼原虫临床分离株的无鞭毛体进行药物高通量筛选。

• 发表时间: 2009-06
• 影响因子: 0.6
• 作者: Mandal, Swati;Maharjan, Mahendra;Ganguly, Sudipto;Chatterjee, Mitali;Singh, Sarman;Buckner, Frederick S;Madhubala, Rentala
• 通讯作者: Madhubala, Rentala