Development and Optimization of Downstream Purification Process of LCY's Carotenoids Products

李长荣类胡萝卜素产品下游纯化工艺开发与优化

• 批准号: 556138-2020
• 负责人: Sheikhzadeh, MehdiM
• 金额: $ 5.46万
• 依托单位: Lambton College of Applied Arts and Technology
• 依托单位国家: 加拿大
• 项目类别: Applied Research and Development Grants - Level 2
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=761510
• 关键词: Development; Optimization; Downstream; Purification; Process

Carotenoids, vitamin A, beta carotene, lycopene, canthaxanthin, and astaxanthin, have many known health benefits and can be converted into nutraceuticals in the form of supplements and food additives. They can also be used as a natural colourant for the food industry, cosmetic industry, and pharmaceutical industry. These carotenoids can also be used as an additive in animal feed formulations.LCY Biosciences Inc. an LCY Chemical Corp. subsidiary, focuses on chemical production through bio-based raw materials and sustainable processes. In 2018, LCY acquired the former BioAmber plant in Sarnia, Ontario with intentions of restarting the production of bio-based succinic acid and also to begin the production of bio-based carotenoids using the LCY Biosciences proprietary biotechnology platform. LCY Biosciences' production of bio-based succinic acid is an established process, but the process of producing bio-based carotenoids is under development. LCY & Lambton College have built a positive partnership through a previous project that worked to optimize LCY's fermentation process. Building on this success, LCY's main objective of this project is to develop and optimize the downstream purification process for the named carotenoids products and establish the QA/QC procedures.The success of this project will be instrumental for LCY to move forward on their carotenoids production line and commercialization. The commercialization of this carotenoid product will not only economically benefit Canada through economic growth and job creation, but it will also environmentally benefit Canada by using agriculture biomass as feedstock instead of petrochemical sources and minimizing the chemical waste production through the fermentation process instead of chemical synthetic method to produce carotenoids.

类胡萝卜素、维生素 A、β 胡萝卜素、番茄红素、角黄素和虾青素具有许多已知的健康益处，并且可以以补充剂和食品添加剂的形式转化为营养保健品。它们还可用作食品工业、化妆品工业和制药工业的天然着色剂。这些类胡萝卜素还可用作动物饲料配方中的添加剂。李长荣生物科学公司是李长荣化学公司的子公司，专注于通过生物基原材料和可持续工艺进行化学品生产。 2018年，李长荣收购了位于安大略省萨尼亚的前BioAmber工厂，旨在重新开始生物基琥珀酸的生产，并开始使用李长荣生物科学专有的生物技术平台生产生物基类胡萝卜素。 LCY Biosciences 生产生物基琥珀酸的工艺已成熟，但生产生物基类胡萝卜素的工艺正在开发中。 LCY 和兰姆顿学院通过之前的一个项目建立了积极的合作伙伴关系，该项目致力于优化 LCY 的发酵工艺。在此成功的基础上，李长荣该项目的主要目标是开发和优化指定类胡萝卜素产品的下游纯化工艺，并建立 QA/QC 程序。该项目的成功将有助于李长荣推进其类胡萝卜素生产线和商业化。这种类胡萝卜素产品的商业化不仅将通过经济增长和创造就业机会使加拿大在经济上受益，而且通过使用农业生物质作为原料而不是石化来源，并通过发酵过程而不是化学合成最大限度地减少化学废物的产生，也将使加拿大在环境上受益生产类胡萝卜素的方法。