Spotlighting biologically active Iron (Fe) chelators within cells

关注细胞内具有生物活性的铁 (Fe) 螯合剂

• 批准号: DP1096029
• 负责人: Prof Paul Bernhardt
• 金额: $ 22.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-04-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096029
• 关键词: Spotlighting; biologically; active; Iron; Fe

Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by attaching light emitting probes to known iron chelators and mapping their location within cells with high resolution fluorescence microscopy. These experiments will spotlight the cellular location of these potential drugs bound to iron for the first time, providing crucial information on their mode of action.

抗癌药物的作用方式不同于传统化疗药物，为避免获得性耐药性带来了希望。之前我们研究了可以进入癌细胞、结合铁并阻止细胞增殖的化合物。然而，细胞中铁的来源有很多，我们不知道这些铁螯合剂从哪里获得铁，也不知道这些铁复合物如何杀死癌细胞。我们将通过将发光探针连接到已知的铁螯合剂并用高分辨率荧光显微镜绘制它们在细胞内的位置来解决这个问题。这些实验将首次聚焦这些与铁结合的潜在药物的细胞位置，提供有关其作用模式的重要信息。