Developing a Biologically-realistic Model-based Approach for Generating Deep Brain Stimulation Patterns

开发基于生物现实模型的方法来生成深部脑刺激模式

• 批准号: 479824
• 负责人: Lankarany Milad
• 金额: $ 61.3万
• 依托单位: Krembil Research Institute (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479824&lang=en
• 关键词: Bio-Signal Processing; Closed-Loop Neuromodulation; Computational Neuroscience; Deep Brain Stimulation; In-Vivo Human Recordings; Movement Disorder; Optimal Pattern Generator; Optimization; Parkinson'S Disease; Stimulation Induced Synaptic Plasticity

Parkinson's disease (PD) is a debilitating movement disorder caused by the loss of dopamine in the basal ganglia. Although there is no cure for PD, symptoms of the disease can be dramatically reduced by standard deep brain stimulation (DBS) that delivers

帕金森病 (PD) 是一种因基底神经节多巴胺缺失而导致的衰弱性运动障碍。尽管帕金森病无法治愈，但通过标准的深部脑刺激 (DBS) 可以显着减轻该疾病的症状。