Applications of Pullulan Nanostructures for Drug Delivery

普鲁兰多糖纳米结构在药物输送中的应用

• 批准号: 573019-2022
• 负责人: Demarquette, NicoleNR
• 金额: $ 2.99万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=754288
• 关键词: Applications; Pullulan; Nanostructures; Drug; Delivery

The main objective of this partnership between the Departments of Biotechnology (Professor Julio Santos), Chemical Engineering (Professor Amilton M. Santos) of the University of São Paulo, Brazil, , Mechanical Engineering of Ecole de Technologie Supérieure de Montréal, ÉTS (Professor Nicole Demarquette) and the Centre de Recherche du Centre Hospitalier de l'Université de Montréal and also ÉTS (Professor Sophie Lerouge) is to develop biomedical applications of Pullulan, a microbial biopolymer. The project will involve two professors from Brazil and two professors from Canada. It will also involve 2 Ph.D. and one M. Eng students. Furthermore, a Master student and one undergraduate student (scientific initiation) working in the laboratory of Pr. dos Santos will be also working on the project.The project will entail the development of three applications:- Application 1: Pullulan will be evaluated for its potential to encapsulate drugs employed in fighting acute viral lung diseases. Micro or nanospheres of pullulan which could be used in a spray for inhalation purposes will be produced. - Application 2: Pullulan, in the form of nonwoven membranes, will be evaluated with regards to its potential for encapsulation of drugs for the treatment of burns.- Application 3: Pullulan will be used to obtain hydrogels and further 3D printed (bioprinted).This project will enable activities in the biomedical field using new biotechnological technologies and natural resources.

巴西圣保罗大学生物技术系（Julio Santos 教授）、化学工程系（Amilton M. Santos 教授）、蒙特利尔高等理工学院机械工程系、ÉTS（ Nicole Demarquette 教授）和蒙特利尔大学医院研究中心以及 ETS （Sophie Lerouge 教授）将开发普鲁兰（一种微生物生物聚合物）的生物医学应用，该项目将涉及两名来自巴西的教授和两名来自加拿大的教授，此外还有一名工程硕士学生。在多斯桑托斯教授实验室工作的硕士生和一名本科生（科学启蒙）也将参与该项目。该项目将需要开发三个应用程序：- 应用程序 1：将评估普鲁兰多糖。将生产可用于吸入喷雾剂的普鲁兰微球或纳米球，以评价其封装药物的潜力，以非织造膜的形式进行评估。考虑到其用于封装治疗烧伤的药物的潜力。-应用 3：普鲁兰多糖将用于获得水凝胶并进一步进行 3D 打印（生物打印）。该项目将使生物医学领域的活动成为可能使用新的生物技术和自然资源的领域。