Dynamic Bonds and Mechanical Properties of Tough Hydrogels: Medical Device and Gel Electrolyte Applications

坚韧水凝胶的动态键和机械性能：医疗器械和凝胶电解质应用

• 批准号: RGPIN-2019-04952
• 负责人: Chung, HyunJoong
• 金额: $ 2.04万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=746863
• 关键词: Dynamic; Bonds; Mechanical; Properties; Tough

BACKGROUND. Dynamic bonds, physical or chemical bonds that can be released by external stimuli in a reversible way, are the most fundamental building block for smart soft materials. While individual dynamic bond may be considered as weak, tough hydrogels (fracture energies of ~10,000 J/m2) has been realized by clustering hydrogen bonds or ionic pairs, which also enables reversible adhesion and self-healing. Despite of the technological importance and empirical successes, current understanding on the correlation between these dynamic bond clusters and the mechanical properties of tough hydrogels at its infancy. This problem is partly because of limited capability of existing experimental tools. SOLUTION. Overall objective of PROGRAM 1 is to establish microchannel cantilever sensor, whose vibration being monitored by laser Doppler vibrometer, as a standard tool for studying the dynamic bonds in (hydro)gels. Established for ultrasensitive detection in biosensing, the two additional merits of the method are picoliter sample size and the variety of vibration modes. The short-term objective (3 years) is to validate the microchannel cantilever technology as a tool for quantitative microrheology. In mid- to long-term plan (5 years and beyond), collaborations with polymer chemists, density functional theory experts, and mechanics theoretician will make quantitative correlations between the characteristics of dynamic bonds (such as individual/clustered bond strength and association/dissociation kinetics) and dynamic mechanical properties (time-resolved evolution of complex moduli). APPPLICATION. With a purpose to complement my current research programs on biomedical devices and battery gel electrolytes, PROGRAM 2 is on molecular design of sticky hydrogels with tunable adhesion. The short- to mid-term objective (5 years) is to fabricate hemorrhage suppressing gel pad that can apply quickly and then release on demand. Long-term objective (beyond 5 years) is to integrate wound-dressing or implantable bioelectronics on the sticky hydrogel platform for advanced healthcare devices, which will be realized by converging my whole research activities. IMPACT. Fundamental understanding on dynamic bonds and its impact to mechanical properties is tremendous across all disciplines of soft materials. Molecular design of sticky and tough hydrogels can be translated to traditional technologies such as rubbers, adhesives, and coatings, as well as to emerging technological areas of biomedical devices, drug delivery, and soft robotics. The proposed DG complements my entire research program to become a self-consistent unity with strong scientific foundation. HQPs trained in my unique and highly interdisciplinary research program will have qualities required for engineers in future society, where convergence between disciplines is the key. Scientific/technological discovery and trained HQPs from the proposed DG will evolve academia and industry in Canada and in the world.

背景。外部刺激可以以可逆的方式释放的动态键，物理或化学键是智能软材料的最基本构建块。虽然可以将单个动态键认为是弱的，但坚硬的水凝胶（骨折的能量约为10,000 j/m2）已通过聚集氢键或离子对实现，这也可以使可逆的粘合剂和自我修复。尽管具有技术意义和经验成功，但目前对这些动态键簇与坚硬水凝胶的机械性能之间的相关性的了解。该问题部分是由于现有实验工具的能力有限。解决方案。程序1的总体目标是建立微通道悬臂传感器，其振动是通过激光多普勒振动监测的，作为研究（Hydro）凝胶中动态键的标准工具。该方法的另外两个优点是在生物传感中建立的，是Picoliter样本量和各种振动模式。短期目标（3年）是验证微通道悬臂技术作为定量微流变学的工具。在长期到长期计划（5年及以后）中，与聚合物化学家，密度功能理论专家和力学理论家的合作将在动态键的特性（例如个体/聚合键强度和关联/分离动力学）和动力学机械特性（复杂模量的时间元素进化）之间建立定量相关性。应用程序。为了补充我当前关于生物医学设备和电池凝胶电解质的研究计划，计划2介绍了带有可调粘合剂的粘性水凝胶的分子设计。短期到中期目标（5年）是在可以迅速应用然后按需释放的出血抑制凝胶垫。长期目标（超过5年）是在高级医疗设备的粘性氢平台上整合伤口穿着或可植入的生物电子学，这将通过收敛我的整个研究活动来实现。影响。在软材料的所有学科中，对动态键及其对机械性能的影响的基本理解是巨大的。粘性和坚硬水凝胶的分子设计可以转化为传统技术，例如橡胶，粘合剂和涂料，以及生物医学设备，药物输送和软机器人技术的新兴技术领域。拟议中的DG完成了我的整个研究计划，以成为具有强大科学基础的自一致的单位。在我独特且高度跨学科的研究计划中接受培训的HQP将具有未来社会中的工程师所需的素质，在这些社会中，学科之间的融合是关键。拟议的DG的科学/技术发现和受过训练的HQP将在加拿大和世界上发展学术界和工业。