Design, Fabrication, and Surface Modification of Multifunctional Nanocomposites Used for Advanced Biosensing Devices

用于先进生物传感设备的多功能纳米复合材料的设计、制造和表面改性

• 批准号: RGPIN-2021-03859
• 负责人: Zhang, Jin
• 金额: $ 2.84万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=746707
• 关键词: Design; Fabrication; Surface; Modification; Multifunctional

The long-term goal of this proposed NSERC DG program is to develop cost-effective, low-energy required, user-friendly sensing arrays for overcoming the challenges of healthcare and the environment to provide accurate and timely information. Multifunctional nanocomposites have shown powerful capabilities in producing miniaturized and multifunctional devices. To reach the full potential of nanomaterials and nanotechnology in the future biosensing industry, Dr. Zhang will continuously develop new multifunctional nanocomposites for advanced biosensing devices. The specific objectives of this proposed NSERC DG program are to (1) synthesize and surface modification of multifunctional nanocomposites to optimize the interface between nanostructures and bioreceptors; (2) to develop new luminescent energy transfer resonance (LRET) biosensors with a non-invasive manner; (3) to design and develop efficient electronic biosensor systems by using two-dimensional nanostructures for remotely harvesting health/environment information.      Our previous research demonstrated that well-defined nanostructures can be modified with biomolecules, e.g. antibody, by combining chemical process and a laser-assisted process, a catalyst-free process. In the proposed activities, we will continuously integrate both the chemical solution process and the laser-assisted process to produce multifunctional nanocomposites. In addition, new LRET biosensor system by using emerging upconversion nanomaterials will be developed which can be used in deep-tissue detection with less or without photon-damage and low toxicity. It is also noted that biocompatible carbon-based nanocomposites with advanced optical, magnetic, electrical, mechanical properties as one-entity have been shown promising potential in the field of point-of-care (POC) devices. Dr. Zhang invented a hybrid graphene-based magnetoresistance (MR) sensor that can be seamlessly integrated with the wireless system due to the capability of MR sensor for quickly converting the change of bioreactions to electronic signals. In the next 5 years, we will tailor the fine structure of carbon-based two-dimensional nanocomposites to achieve real-time and remote detection.      The proposed research program will provide a highly multidisciplinary platform for students and young researchers to gain experiences in nanofabrication, design, and development of advanced and miniaturized biosensor systems to quickly detect the bioprocesses occurring in the cell, or body fluids, or ecosystem. Diversity and increased gender quality are the priority in recruiting the trainees. The proposed NSERC DG program will efficiently transfer new knowledge and technology to industry, and to provide a pool of human resources available for the high-tech sector of the Canadian industry and for the development of emerging sensing technology, which position the country as a major competitor on the global market.

该提议的NSERC DG计划的长期目标是开发具有成本效益，低能的，用户友好的感应阵列，以克服医疗保健和环境的挑战，以提供准确，及时的信息。多功能纳米复合材料在生产微型和多功能设备方面表现出强大的功能。为了在未来的生物传感行业中充分发挥纳米材料和纳米技术的全部潜力，张博士将继续开发新的多功能纳米复合材料，用于先进的生物传感设备。该提出的NSERC DG程序的特定目标是（1）综合和表面修饰多功能纳米复合材料，以优化纳米结构和生物感受器之间的接口； （2）以非侵入性方式开发新的发光能量传递共振（LRET）BIOSENOR； （3）通过使用二维纳米结构来设计和开发有效的电子生物传感器系统，以远程收集健康/环境信息。我们以前的研究表明，可以通过生物分子（例如抗体，通过结合化学过程和激光辅助过程，无催化剂的过程。在拟议的活动中，我们将继续整合化学溶液过程和激光辅助过程，以产生多功能纳米复合材料。此外，将开发出新的LRET生物传感器系统通过使用新出现的纳米材料来开发，该系统可用于较少或没有光子破坏和低毒性的深度组织检测中。还注意到，具有先进的光学，磁性，电气，机械性能的生物相容性碳基纳米复合材料已显示出在护理点（POC）设备领域中有希望的潜力。张博士发明了一种基于混合石墨烯的磁阻（MR）传感器，该传感器可以与无线系统无缝集成，因为MR传感器能够快速将生物反应转换为电子信号的变化。在接下来的5年中，我们将定制基于碳的二维纳米复合材料的精细结构，以实现实时和远程检测。拟议的研究计划将为学生和年轻研究人员提供一个高度的多学科平台，以获得纳米制作，设计和开发高级和微型生物传感器系统的经验，以快速检测细胞中发生的生物处理，或者体液或生态系统。多样性和提高性别质量是招募培训的优先事项。拟议的NSERC DG计划将有效地将新的知识和技术转移到工业上，并为加拿大行业的高科技领域以及新兴敏感技术的发展提供可用的人力资源，该技术将该国定位为全球市场上的主要竞争对手。