Promoting in vitro propagation of primary human hepatocytes as organoids using cues from natural liver regeneration

利用自然肝再生的线索促进原代人肝细胞作为类器官的体外增殖

• 批准号: 471981
• 负责人: Lotto Jeremy A
• 金额: $ 10.93万
• 依托单位: University of Washington (Seattle)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=471981&lang=en
• 关键词: Cell Signaling; Genomics; Liver; Liver Disease; Organoids; Regenerative Medicine; Tissue Regeneration

Liver disease is a severe and accelerating global health crisis and the only cure is organ transplantation. Novel regenerative medicine approaches show promise, but require unattainably large numbers of hepatocytes, the main functional cells of the liver.

肝病是一场严重且不断加剧的全球健康危机，唯一的治疗方法是器官移植。新型再生医学方法显示出希望，但需要大量肝细胞（肝脏的主要功能细胞）。