Structure-property relationships in ionically substituted bioactive glasses.

离子取代生物活性玻璃的结构-性能关系。

• 批准号: RGPIN-2019-04634
• 负责人: Towler, Mark
• 金额: $ 2.84万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=737756
• 关键词: Structure; property; relationships; ionically; substituted

A philosophy: rather than attempting to recreate the complexity of living tissues ex vivo, synthetic materials can be formulated that offer mechanical integrity whilst interacting with cells to unlock the body's inherent ability to self-repair. The Clinical Materials Group (CMG) at Ryerson University, under the leadership of Towler, is designing glass-based materials with properties tailored by ionic incorporation in order to engage this philosophy. The program will build on existing published (156 peer-reviewed papers) and patented (six in total; two in the relevant space) research in Towler's laboratory by recruiting students to fulfil four objectives: A.Advance knowledge. The program will expand the fundamental understanding of the role that specific ionic dopants, in quantifiable amounts, have on the physical, mechanical and in-vitro biological properties of ionomeric glasses and cementitious materials manufactured from them. The program will have three streams: 1. Synthesis of glasses and glass polyalkenoate cements (GPCs) formulated to be sufficiently viscous for load bearing. 2. Incorporation of Gallium ions into glasses by sol-gel electro-spinning. 3. Development of a resorbable GPC. B.Inspire the next generation. Highly qualified personnel (HQP) will be trained for the academic, industrial and regulatory industries. Their skills will be honed by placements with Towler's academic, clinical and industrial collaborators across Canada. C.Confirm the value of R&D investment. Advancements made through the program will result in IP for commercial exploitation. The work will interest Canadian start-ups, small to medium enterprises (SME) and multinational industry. Towler has both licensed (Opus-Fil+, DS&D, UK) and spun-off (Crescent Ops, London, UK) technology. D.Increase visibility of research. Towler will continue to publish extensively in the literature, at the least maintaining his existing rate (~15 papers, annually) and ensuring HQP disseminate their work at leading scientific conferences. In his first five years in Canada (2013-2018), Towler secured over C$2.6m from NSERC and CIHR to graduate eight PhD and four MASc students and mentor four PDFs; the group currently has 11 graduate students and three PDFs; all funded by federal grants with a 50:50 gender balance between men and women. New HQP will be recruited from the materials, biology and engineering fields; the remit being to train them in areas of strategic interest to Canada.  Discovery deliverables may be exploited through future NSERC I2I or Collaborative Research & Development (CRD) or NSERC/CIHR Collaborative Health Research Project (CHRP) grants and, with follow-on accreditation activities, could improve orthopedic procedures leading to shorter hospital stays and reduced healthcare costs.

一种哲学：可以配制合成材料，而不是试图重现生存组织的复杂性，而是可以提供机械完整性，同时与细胞相互作用以解锁人体对自我修复的遗传性。瑞尔森大学（Ryerson University）的临床材料组（CMG）在托勒（Towler）的领导下，正在设计基于玻璃的材料，其物业由Ionic Incorporated Corporations量身定制，以吸引这种理念。该计划将建立在现有已发表的（156份同行评审的论文）的基础上，并通过招募学生实现四个目标：A. A.Advance知识，在Towler的实验室中获得专利（共有6篇；在相关空间中有2个）。该计划将扩展对特定离子掺杂剂在可量化量中具有的作用的基本理解，这些量子对离子玻璃的物理，机械和体外生物学特性以及用它们制造的胶结材料具有的作用。将有三个流：1。玻璃和玻璃多烷烃水泥（GPC）的合成，该水泥（GPC）配制了足够的粘性，以供负载轴承。 2。通过溶胶 - 凝胶电旋转将凝胶离子掺入玻璃杯中。 3。可吸收GPC的开发。 B.SINSPIRE下一代。高素质的人员（HQP）将接受学术，工业和监管行业的培训。与托勒在加拿大各地的学术，临床和工业合作者的安置，他们的技能将受到尊重。 C.确认研发投资的价值。通过该计划的进步将导致IP进行商业开发。这项工作将使加拿大初创企业，中小型企业（SME）和跨国公司感兴趣。 Towler已获得许可（Opus-FIL+，DS＆D，UK）和Spun-Off（Crescent Ops，伦敦，英国）技术。 D.研究的知名度。 Towler将继续在文献中广泛发表，至少保持其现有率（每年约15篇论文），并确保HQP在领先的科学会议上传播他们的工作。在加拿大的头五年（2013-2018）中，沃勒从NSERC和CIHR获得了260万加元的$ 260万加元，毕业了八位博士学位和四名MASC学生以及导师四个PDF；该小组目前有11名研究生和3个PDF；全部由男女之间的联邦赠款资助，性别平衡为50:50。新的HQP将从材料，生物学和工程领域招募；在加拿大具有战略兴趣领域培训他们的秘诀。可以通过未来的NSERC I2I或协作研究与开发（CRD）或NSERC/CIHR协作健康研究项目（CHRP）赠款来探索发现可交付成果，并且通过随后的认证活动，可以改善骨科程序，从而改善近部医院的住院和医疗保健费用。