Inorganic Biomaterials with Therapeutic Potential

具有治疗潜力的无机生物材料

• 批准号: RGPIN-2014-06127
• 负责人: Towler, Mark
• 金额: $ 2.11万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638073
• 关键词: Inorganic; Biomaterials; Therapeutic; Potential

Bone fractures cost Canadian healthcare providers over $1.3 billion each year and surgical reparation of these fractures can result in additional costs due, in part, to bacterial ingress (caries) during surgery. For example, over 10% of the 15,953 hip replacement surgeries performed in Canadian hospitals during the 2009-10 fiscal year were revision surgeries. These incur double the cost of the initial surgery and contribute significantly to the Canadian hospital wait-times crisis. Orthopedic devices are designed to surgically address physical damage, with medical treatment being supplied by pharmaceutical intervention. For sufferers of osteoporosis, the physical damage concerns reduced bone density; for sufferers of cancer, destruction of healthy bone; and for sufferers of caries, bacteria-driven erosion. The only truly successful bone replacement material is bone itself, harvested either by auto-graft (bone donated from the same patient) or allo-graft (bone donated from another patient). However, because of the limitations of such grafts (e.g. donor-site morbidity, pain, infection, limited supply and inconsistent osteogenic activity) there is a drive toward developing synthetic alternatives that are suitable for load-bearing applications in the skeleton. Ideally these materials will impart a therapy at the fracture site in order to minimize the need for follow-up surgery. Thus the objective of this research is to develop synthetic materials that interact with cells to unblock the body's ability to self-repair. This program will design and synthesize novel materials that incorporate ionic species, or combinations of ionic species, known to impart therapeutic responses in bone. It will expand expertise in the applicant's laboratory by recruiting students from a variety of academic backgrounds, thereby creating a multidisciplinary environment where these unique materials will be synthesized and evaluated using both standard and novel techniques. In the short term, the project will provide a stimulating training venue for Ryerson students and research fellows in an engineering environment addressing a clinical problem. In the long term, this research will advance the applications of glass and ceramics in the field of orthopedics, leading to broader technological innovation. Through participation in the research program, highly qualified personnel (HQP) will develop interdisciplinary skills at the interface of the materials and clinical sciences. These HQPs will subsequently populate both Canadian academia and industry resulting in tangible benefits to the people of Canada.

骨折每年使加拿大医疗保健提供者的成本超过13亿加元，这些骨折的手术赔偿可能会导致额外的费用，部分原因是在手术过程中细菌入口（龋齿）。例如，在2009-10会计年度，在加拿大医院进行的15,953次髋关节置换手术中，超过10％是修订手术。这些产生了初始手术的成本的两倍，并为加拿大医院的等待时间危机做出了重大贡献。骨科设备旨在通过药物干预提供医疗治疗，旨在通过手术解决身体损害。对于骨质疏松症的患者，身体损害涉及骨密度降低。对于癌症患者，健康骨骼的破坏；对于龋齿的患者，细菌驱动的侵蚀。唯一真正成功的骨骼替代材料是骨本身，由自动移植物（从同一患者捐赠）或异晶植物（从另一名患者捐赠的骨头）收获。但是，由于这种移植物的局限性（例如，供体部位的发病率，疼痛，感染，有限的供应和不一致的成骨活动），因此驱动着开发适合骨架中负载应用的合成替代方案。理想情况下，这些材料将在骨折部位进行治疗，以最大程度地减少对随访手术的需求。因此，这项研究的目的是开发与细胞相互作用的合成材料，以解除身体自我修复的能力。该程序将设计和合成融合离子物种或离子物种组合的新型材料，该物种已知会在骨骼中赋予治疗反应。它将通过招募来自各种学术背景的学生来扩大申请人实验室的专业知识，从而创建一个多学科的环境，在此环境中，这些独特的材料将通过标准和新颖的技术综合和评估。在短期内，该项目将为Ryerson学生提供刺激性的培训场所，并在解决临床问题的工程环境中的研究研究员。从长远来看，这项研究将推动玻璃和陶瓷在骨科领域的应用，从而导致更广泛的技术创新。通过参与研究计划，高素质的人员（HQP）将在材料和临床科学的界面上发展跨学科的技能。这些HQP随后将在加拿大学术界和行业群体中填充，从而为加拿大人民带来切实的好处。