Quantifying knee joint mechanical exposures and tissue response in high knee flexion

量化膝关节高屈曲时的机械暴露和组织反应

• 批准号: RGPIN-2019-04109
• 负责人: Acker, Stacey
• 金额: $ 1.97万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=737415
• 关键词: Quantifying; knee; joint; mechanical; exposures

Floor-level postures (eg. kneeling, squatting) are essential for many daily activities (household chores, home maintenance, religious practices) and occupations (mining, childcare, floor installation, masonry, landscaping), yet knee joint mechanics and the corresponding joint tissue behaviours in these high knee flexion (knee bending) postures are not well understood. While some research has estimated high knee joint loads in these postures (beyond levels that healthy tissue can withstand), there is scientific evidence to support the idea that healthy joint tissues can adapt to withstand high joint loads. In healthy individuals, changes have been observed in how people move after prolonged kneeling, which may play a role in this adaptation. My research program aims to: 1.Advance the novel, computational knee joint model, developed in my lab, to best represent knee joint movements and loading throughout the full range of knee joint motion. 2.Create a non-invasive, wearable system to measure the frequency and duration of floor-level tasks in activities of daily living. Modeled joint loads (from 1, above) and measurements from this system will be used to determine a "total load." The proposed work will determine if healthy, living knee joint cartilage exhibits different strain (deformation) behaviour depending on the total load to which it is typically exposed. 3.Test whether the changes in movement strategies observed after kneeling could be a result of changes in the ligaments. My research program will contribute innovative approaches to anatomically-based computational knee modeling. It will deliver the first validated full-flexion knee model and exposure measurement system. My proposed research will make Canada a leader in this area by clarifying mechanisms for cartilage conditioning, characterizing the loads associated with these postures, and providing simple tools to measure how often, and for how long, these postures are assumed, using wearable technology. This work has high potential for impact beyond the scope of this proposal. The identified mechanisms for adaptation related to floor-level activities of daily living can be used in future prevention efforts to reduce the risk of tissue damage that has been indirectly linked to kneeling and squatting. Some countries designate knee osteoarthritis associated with deep knee bending at work as an occupational disease. Preventing this type of osteoarthritis becomes more pressing to Canadians as the workforce ages. Trainees in my research program will apply state-of-the-art modeling, motion tracking, and imaging approaches to achieve these timely objectives. They will gain leadership, technical, and scientific skills that will enable them to make a strong impact in the fields of engineering, science, and medicine in Canada.

地板水平的姿势（例如跪下，蹲下）对于许多日常活动（家庭杂务，家庭维护，宗教练习）和职业（采矿，托儿，托儿，地板安装，砖石，砌体，园地环境）至关重要，但是膝盖关节机械和相应的关节组织在这些高膝盖弯曲（膝盖弯曲）中尚不清楚。尽管一些研究估计这些姿势中的高膝关节负荷（超出健康组织可以承受的水平），但有科学的证据支持健康的关节组织可以适应高关节载荷的观念。在健康的个体中，人们在长时间跪下后如何移动时观察到了变化，这可能在这种适应中起作用。我的研究计划的目的是：1。在我的实验室中开发的新颖的计算膝关节模型，以最好地代表膝关节运动和在整个膝关节运动范围内的载荷。 2.创建一种无创，可穿戴的系统，以测量日常生活活动中地板级任务的频率和持续时间。建模的关节载荷（从上面的1个），该系统的测量值将用于确定“总载荷”。拟议的工作将确定健康，活膝关节软骨是否表现出不同的应变（变形）行为，具体取决于通常暴露的总负荷。 3.测试跪下后观察到的运动策略的变化是否可能是韧带变化的结果。我的研究计划将为基于解剖学的计算膝盖建模提供创新方法。它将提供第一个经过验证的全屈服膝盖模型和曝光测量系统。我提出的研究将通过阐明软骨调节的机制，表征与这些姿势相关的负载，并提供简单的工具来测量使用可穿戴技术的频率，并在假定这些姿势的情况下衡量这些姿势的频率，并提供简单的工具，从而使加拿大成为该领域的领导者。这项工作具有超出该提案范围的影响力的很高潜力。适应与日常生活相关的适应性的确定机制可用于未来的预防工作，以减少与跪着和蹲下并间接相关的组织损伤风险。一些国家指定膝盖骨关节炎与工作中的深膝弯曲相关。随着劳动力年龄的增长，防止这种类型的骨关节炎变得更加紧迫加拿大人。 我的研究计划中的受训者将采用最新的建模，运动跟踪和成像方法来实现这些及时的目标。他们将获得领导，技术和科学技能，使他们能够在加拿大的工程，科学和医学领域产生强大的影响。