Quantifying the Mechanism and Impact of Hip Extensor Muscle Dysfunction During Aerobic Exercise in Hip Osteoarthritis

量化髋部骨关节炎有氧运动期间髋部伸肌功能障碍的机制和影响

基本信息

批准号：
10667426
负责人：
Michael A Samaan
金额：
$ 12.8万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10667426
关键词：
Advisory Committees Aerobic Exercise Age Aging Area Biochemical Biological Markers Biomechanics Biometry Cartilage Cartilage Matrix Chronic Clinical Data Degenerative polyarthritis Development Disease Disease Progression Elderly Exercise Exhibits Extensor Fibrosis Functional disorder Goals Health Hip Joint Hip Osteoarthritis Hip Pain Hip region structure Image Intervention Knee Osteoarthritis Knowledge Literature Magnetic Resonance Imaging Measures Mechanical Stress Mechanics Mentored Research Scientist Development Award Muscle Muscle function Musculoskeletal Pain Patient Self-Report Patients Physical therapy Population Principal Investigator Protocols documentation Recommendation Research Research Personnel Resources Serum Stress Tests Techniques Therapeutic Torque Total Hip Replacement Training United States Work age related aging population career chronic pain patient comparison control exercise intervention exercise program gait rehabilitation improved innovation insight joint loading mammalian COMP multidisciplinary multimodality muscle physiology novel novel imaging technique preservation programs prospective simulation skills symptom treatment

项目摘要

Project Summary/Abstract Hip osteoarthritis (OA) impacts approximately 25% of the population over the age of 45 years. Current conservative treatments include exercise-based programs yet these interventions are ineffective in reducing hip OA-related clinical and functional abnormalities. One limitation of these exercise programs is the lack of evidence used to establish these treatment paradigms, which leads to the ineffectiveness of these programs in treating hip OA. Current experimental protocols used to inform exercise programs for the hip OA population lack precision in measuring hip joint muscular dysfunction. Therefore, there is a need to establish an experimental platform that can precisely measure hip joint muscular dysfunction. The novel experimental platform proposed in this application will be able to precisely assess hip muscle dysfunction and will provide clinicians with the evidence needed to develop effective multi-disciplinary, exercise programs for conservative treatment of symptomatic hip OA. The principal investigator (PI) of this K01 award will develop a novel, multi-modal experimental platform that will precisely measure the effects of hip extensor muscle dysfunction in patients with symptomatic hip OA. The PI will utilize novel imaging techniques and assessment of muscle torque development to assess the pathomechanism of hip extensor dysfunction in patients with symptomatic hip OA. The corresponding effects of hip extensor dysfunction during aerobic exercise (mechanical stress test) will be assessed in patients with symptomatic hip OA. Musculoskeletal simulations and serum-based biomarkers of cartilage health will be used to quantify the changes that occur in hip joint contact forces and systemic cartilage turnover/synthesis, respectively, during the mechanical stress test. These study results will be used to determine the relationship of gluteus maximus muscle fibrosis and hip extensor rate of torque development with changes in hip loading, cartilage health and self-reported hip pain in the symptomatic hip OA population. Upon completion of this K01 project, the applicant will possess the knowledge needed to implement this novel experimental platform on a large scale basis to assess the longitudinal relationship between hip extensor dysfunction with hip OA disease progression in the subsequent R01 application. The PI has developed a strong training plan in aging, muscle-imaging, muscle-physiology and biochemical biomarkers. The PI has established a diverse advisory committee with expertise in aging, physical therapy, biomechanics, muscle-physiology, exercise for OA, biomarkers of OA and biostatistics. This K01- award will provide the PI with the training and resources needed to accomplish the goals of this project and will lead the PI towards a successful career as an independent investigator in aging-related research.

项目摘要/摘要髋关节关节炎（OA）影响了45岁以上约25％的人口。当前的保守的治疗包括基于运动的计划，但这些干预措施在减少方面无效髋关节与OA相关的临床和功能异常。这些锻炼计划的局限性之一是缺乏用于建立这些治疗范式的证据，这导致这些计划的无效性治疗髋关节OA。当前用于为髋关节人群提供锻炼计划的实验协议缺乏测量髋关节肌肉功能障碍的精度。因此，有必要建立可以精确测量髋关节肌肉功能障碍的实验平台。新颖的实验本应用程序中提出的平台将能够精确评估臀部肌肉功能障碍，并将提供为了制定有效的多学科，锻炼计划所需的证据所需的临床医生有症状的髋关节OA治疗。该K01奖的主要研究员（PI）将开发一个新颖的多模式实验平台这将精确地衡量髋关节肌肉功能障碍对有症状的髋关节OA患者的影响。 PI将利用新颖的成像技术和肌肉扭矩发育的评估来评估症状性髋关节OA患者的髋关节伸肌功能障碍的病理机制。相应的效果有氧运动过程中的髋关节伸肌功能障碍（机械应力测试）将在患者中评估有症状的髋关节OA。将使用肌肉骨骼模拟和基于血清的软骨健康生物标志物为了量化髋关节接触力和全身软骨周转/合成中发生的变化，在机械应力测试期间分别。这些研究结果将用于确定关系臀大肌纤维化和髋关节发育的髋关节伸肌速率随着髋关节的变化，有症状的髋关节OA种群中软骨健康和自我报告的髋部疼痛。完成此K01后项目，申请人将拥有在A上实施此新型实验平台所需的知识大规模的基础，以评估髋关节伸肌功能障碍与髋关节疾病之间的纵向关系随后的R01应用程序中的进展。 PI已制定了衰老，肌肉成像，肌肉生理学和生化生物标志物。 PI已成立了一个多元化的咨询委员会，具有老龄化，物理的专业知识治疗，生物力学，肌肉生理学，OA运动，OA和生物统计学的生物标志物。这个K01- 奖项将为PI提供实现该项目目标所需的培训和资源，并将领导PI迈向与衰老相关研究的独立研究者的成功职业生涯。