ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
基本信息
- 批准号:RGPIN-2017-04658
- 负责人:
- 金额:$ 4.95万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
beta-cell lines; Exocytotic machinery molecules; extracellular matrix; Glucose-stimulated insulin secretion; Insulin-producing beta cells; Integrin; primary human and mouse adult islets; singling pathway
β细胞线;胞胞胞菌机械分子;细胞外基质;葡萄糖刺激的胰岛素分泌;产生胰岛素的β细胞;整合素;主要人类和小鼠成人胰岛;单身路径
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wang, Rennian其他文献
Aldehyde dehydrogenase 1 activity in the developing human pancreas modulates retinoic acid signalling in mediating islet differentiation and survival
- DOI:
10.1007/s00125-013-3147-y - 发表时间:
2014-04-01 - 期刊:
- 影响因子:8.2
- 作者:
Li, Jinming;Feng, Zhi C.;Wang, Rennian - 通讯作者:
Wang, Rennian
Critical role of β1 integrin in postnatal beta-cell function and expansion
- DOI:
10.18632/oncotarget.17969 - 发表时间:
2017-09-08 - 期刊:
- 影响因子:0
- 作者:
Peart, Jason;Li, Jinming;Wang, Rennian - 通讯作者:
Wang, Rennian
β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival
- DOI:
10.1002/path.2577 - 发表时间:
2009-10-01 - 期刊:
- 影响因子:7.3
- 作者:
Saleem, Saira;Li, Jinming;Wang, Rennian - 通讯作者:
Wang, Rennian
Fibrin supports human fetal islet-epithelial cell differentiation via p70s6k and promotes vascular formation during transplantation
- DOI:
10.1038/labinvest.2015.74 - 发表时间:
2015-08-01 - 期刊:
- 影响因子:5
- 作者:
Riopel, Matthew;Li, Jinming;Wang, Rennian - 通讯作者:
Wang, Rennian
Integrins and extracellular matrices in pancreatic tissue engineering.
- DOI:
10.2741/s39 - 发表时间:
2009-06-01 - 期刊:
- 影响因子:0
- 作者:
Krishnamurthy, Mansa;Wang, Rennian - 通讯作者:
Wang, Rennian
Wang, Rennian的其他文献
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{{ truncateString('Wang, Rennian', 18)}}的其他基金
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2020
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2019
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2018
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2017
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Role of fibrin-integrin interactions in supporting 2D and 3D pancreatic islet growth and function
纤维蛋白-整合素相互作用在支持 2D 和 3D 胰岛生长和功能中的作用
- 批准号:
239981-2011 - 财政年份:2016
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Role of fibrin-integrin interactions in supporting 2D and 3D pancreatic islet growth and function
纤维蛋白-整合素相互作用在支持 2D 和 3D 胰岛生长和功能中的作用
- 批准号:
239981-2011 - 财政年份:2014
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Role of fibrin-integrin interactions in supporting 2D and 3D pancreatic islet growth and function
纤维蛋白-整合素相互作用在支持 2D 和 3D 胰岛生长和功能中的作用
- 批准号:
239981-2011 - 财政年份:2013
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Role of fibrin-integrin interactions in supporting 2D and 3D pancreatic islet growth and function
纤维蛋白-整合素相互作用在支持 2D 和 3D 胰岛生长和功能中的作用
- 批准号:
239981-2011 - 财政年份:2012
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Role of fibrin-integrin interactions in supporting 2D and 3D pancreatic islet growth and function
纤维蛋白-整合素相互作用在支持 2D 和 3D 胰岛生长和功能中的作用
- 批准号:
239981-2011 - 财政年份:2011
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
Determination of the mechanisms by which Beta1-integrin regulates islet cell survival
确定 Beta1-整合素调节胰岛细胞存活的机制
- 批准号:
239981-2005 - 财政年份:2010
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
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SOCS1是葡萄膜黑色素瘤对免疫治疗反应的关键调节因子
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ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
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539534-2019 - 财政年份:2019
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University Undergraduate Student Research Awards
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2019
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
ß1-integrin is a crucial regulator of the exocytotic machinery in pancreatic beta-cells, affecting insulin secretion and integrin trafficking.
α1-整合素是胰腺β细胞胞吐机制的重要调节因子,影响胰岛素分泌和整合素运输。
- 批准号:
RGPIN-2017-04658 - 财政年份:2018
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual