Ultra-sensitive sensors for the detection of onset metastatic cancers from blood samples

用于从血液样本中检测转移性癌症的超灵敏传感器

• 批准号: 571353-2021
• 负责人: Venkatakrishnan, Krishnan
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729151
• 关键词: Ultra; sensitive; sensors; detection; onset

Cancer metastasis refers to cancer cell spread to tissues and organs beyond tumor origin and the formation of new tumors. The process is a cascade of biological events that are unclear due to its complex nature. Detecting early-stage metastasis remains challenging. Despite recent clinical treatment advances, metastasis is the most life-threatening event for cancer patients. In recent years, blood samples containing tumor and tumor stem cells, have gained intense research interest, for their possibility to accurately portray metastasis in real-time. However, sophisticated protocols of existing blood test technologies is of low sensitivity and requires isolation, a major roadblocks in detection of metastasis.This collaboration merges the technological invention of Ryerson University (RU) with findings in cancer cascading from University of Wisconsin, Milwaukee (UWM) to develop a quantum-sensor based diagnostic tool to detect cancer metastasis onset with a simple dry-lab blood test. We will investigate cancer metastasis cascades at a molecular level to identify markers for early stage cancer metastasis diagnosis. Results will have potential to radically change blood-based diagnostic approaches and create a low-cost, easy-to-operate, rapid diagnostic method that captures cancer metastasis onset with blood as a primary source of information.Findings will lead to a minimally invasive, broadly available clinical assessment tool for routine bedside use, applicable to most common types of cancer, for highly accurate point-of-care diagnosis, improving treatment outcomes, saving lives, and reducing costs of cancer treatment. New spin-off businesses to manufacture the device will generate employment opportunities in mechanical engineering and biomedical industries, strengthening Canada's economic base and economic growth.

癌症转移是指癌细胞扩散到肿瘤起源以外的组织和器官并形成新的肿瘤。该过程是一系列生物事件的级联，由于其复杂的性质，这些事件尚不清楚。检测早期转移仍然具有挑战性。尽管最近的临床治疗取得了进展，但转移仍然是癌症患者最危及生命的事件。近年来，含有肿瘤和肿瘤干细胞的血液样本因其能够实时准确描绘转移的可能性而引起了人们的强烈研究兴趣。然而，现有血液检测技术的复杂方案灵敏度低且需要隔离，这是检测转移的主要障碍。这项合作将瑞尔森大学 (RU) 的技术发明与威斯康星大学密尔沃基分校 (UWM) 的癌症级联发现相结合）开发一种基于量子传感器的诊断工具，通过简单的干实验室血液测试来检测癌症转移的发生。我们将在分子水平上研究癌症转移级联，以确定早期癌症转移诊断的标志物。结果将有可能从根本上改变基于血液的诊断方法，并创建一种低成本、易于操作、快速的诊断方法，以血液作为主要信息来源捕获癌症转移的发生。研究结果将导致一种微创、广泛可用的临床评估工具，适合常规床边使用，适用于最常见的癌症类型，可实现高度准确的护理点诊断、改善治疗结果、挽救生命并降低癌症治疗成本。制造该设备的新衍生企业将为机械工程和生物医学行业创造就业机会，从而加强加拿大的经济基础和经济增长。