Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

血小板友好型储存袋可提高储存质量、延长保质期并防止生物膜生长

• 批准号: 549667-2020
• 负责人: Kizhakkedathu, Jayachandran
• 金额: $ 9.2万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722592
• 关键词: Platelet; friendly; storage; bags; improve

This research addresses serious challenges associated with blood transfusion: quality ofstored platelets and the prevention of bacterial growth. Platelet transfusion is used for treatingpatients suffering e.g. from cancer and excessive blood loss (accident victims). In NorthAmerica, approximately 4.5 million units of platelets are transfused every year. Currentlyplatelets are stored in plastic containers which are originally not designed to store platelets atroom temperature. There is very little innovation in platelet storage over the years. The qualityof stored platelets decreases due to the surface induced damage by the current conventionalstorage bags. Transfusion of bacterial contaminated platelets is another longstanding seriouscomplication. The incidence of bacterial contamination associated with platelet storage is ashigh as 1 per every 1500 units and represents a huge cost as every platelet unit is tested forcontamination to avoid septic reactions in patients. Thus improving the quality of storedplatelets, shelf-life and develop methods to prevent bacterial growth will significantlyavailability, reduce the wastage and increase transfusion efficiency. Our project seeks novelplatelet storage devices based on latest breakthroughs at UBC on novel one-step universalantibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposeddevice will improve the quality of stored platelets and increase the shelf-life by providing anenvironment that is highly cell compatible in comparison to the current storage bags. Weanticipate that this will extend the storage life of platelets significantly compared to the current5 days. Importantly this new device can be used in conjunction with the newly approvedpathogen inactivation technologies by improve the platelet quality. The benefits over currentmethods will be substantial as it avoid wastage and increase safety and have significant costsavings to our health system.

这项研究解决了与输血相关的严峻挑战：储存血小板的质量和预防细菌生长。血小板输注用于治疗患有以下疾病的患者：癌症和失血过多（事故受害者）。在北美，每年大约输注 450 万单位的血小板。目前，血小板储存在塑料容器中，而这些容器最初并不是设计用于在室温下储存血小板的。多年来，血小板储存方面的创新很少。现有的常规储存袋会因表面损伤而导致储存的血小板质量下降。输注细菌污染的血小板是另一个长期存在的严重并发症。与血小板储存相关的细菌污染发生率高达每 1500 个单位 1 个，这意味着巨大的成本，因为每个血小板单位都要经过污染测试，以避免患者出现败血症反应。因此提高储存血小板的质量、保质期并开发防止细菌生长的方法将显着提高可用性、减少浪费并提高输血效率。我们的项目基于 UBC 在新型一步式通用抗菌膜涂层和清除血小板活化分子抑制剂方面的最新突破，寻求新型血小板存储设备。与当前的储存袋相比，所提出的装置将通过提供高度细胞相容的环境来提高储存血小板的质量并延长保质期。我们预计，与目前的 5 天相比，这将显着延长血小板的保存期限。重要的是，这种新设备可以与新批准的病原体灭活技术结合使用，提高血小板质量。与现有方法相比，其优势将是巨大的，因为它可以避免浪费，提高安全性，并为我们的卫生系统节省大量成本。