Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

血小板友好型储存袋可提高储存质量、延长保质期并防止生物膜生长

• 批准号: 549667-2020
• 负责人: Kizhakkedathu, Jayachandran
• 金额: $ 17.16万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699483
• 关键词: Platelet; friendly; storage; bags; improve

This research addresses serious challenges associated with blood transfusion: quality of stored platelets and the prevention of bacterial growth. Platelet transfusion is used for treating patients suffering e.g. from cancer and excessive blood loss (accident victims). In North America, approximately 4.5 million units of platelets are transfused every year. Currently platelets are stored in plastic containers which are originally not designed to store platelets at room temperature. There is very little innovation in platelet storage over the years. The quality of stored platelets decreases due to the surface induced damage by the current conventional storage bags. Transfusion of bacterial contaminated platelets is another longstanding serious complication. The incidence of bacterial contamination associated with platelet storage is as high as 1 per every 1500 units and represents a huge cost as every platelet unit is tested for contamination to avoid septic reactions in patients. Thus improving the quality of stored platelets, shelf-life and develop methods to prevent bacterial growth will significantly availability, reduce the wastage and increase transfusion efficiency. Our project seeks novel platelet storage devices based on latest breakthroughs at UBC on novel one-step universal antibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposed device will improve the quality of stored platelets and increase the shelf-life by providing an environment that is highly cell compatible in comparison to the current storage bags. We anticipate that this will extend the storage life of platelets significantly compared to the current 5 days. Importantly this new device can be used in conjunction with the newly approved pathogen inactivation technologies by improve the platelet quality. The benefits over current methods will be substantial as it avoid wastage and increase safety and have significant cost savings to our health system.

这项研究解决了与输血相关的严峻挑战：输血质量 储存血小板并防止细菌生长。血小板输注用于治疗 患者患有例如癌症和失血过多（事故受害者）。位于北部 美国每年约有 450 万单位的血小板被输注。现在 血小板储存在塑料容器中，该容器最初并不是为储存血小板而设计的 室温。多年来，血小板储存方面的创新很少。品质 由于当前常规方法造成的表面损伤，储存的血小板数量减少 储物袋。输入细菌污染的血小板是另一个长期存在的严重问题 并发症。与血小板储存相关的细菌污染发生率如下 高达每 1500 个单位 1 个，这意味着巨大的成本，因为每个血小板单位都要进行测试 避免污染，避免患者出现脓毒反应。从而提高存储质量 血小板、保质期和开发防止细菌生长的方法将显着 可用性，减少浪费并提高输血效率。我们的项目寻求新颖 基于 UBC 新型一步通用技术最新突破的血小板储存装置 清除血小板活化分子的抗菌膜涂层和抑制剂。拟议的 设备将提高储存血小板的质量并通过提供 与当前的存储袋相比，该环境具有高度的细胞兼容性。我们 预计与目前的方法相比，这将显着延长血小板的保存期限 5天。重要的是，这种新设备可以与新批准的 通过提高血小板质量的病原体灭活技术。相对于当前的优势 这些方法将非常重要，因为它可以避免浪费并提高安全性，并且成本高昂 为我们的卫生系统节省开支。