Sprayable anti-infective and anti-biofilm coatings for industrial, agricultural, and consumer applications

适用于工业、农业和消费应用的可喷涂抗感染和抗生物膜涂层

• 批准号: 570723-2021
• 负责人: Hoare, Todd
• 金额: $ 16.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=720697
• 关键词: Sprayable; anti; infective; biofilm; coatings

The COVID-19 pandemic and increasing concerns over emerging antibiotic resistant bacteria have made the development of new approaches to deactivate pathogens on surfaces increasingly critical. The eradication of dense biofilms (combinations of bacteria and extracellular polymers) that can develop in areas as diverse as biomedical implants to bioreactors to oil pipelines is even more challenging than killing a single bacteria, with all of the (very few) products now available for biofilm sterilization requiring the use of very corrosive or environmentally toxic components. While some engineered surfaces have demonstrated potential for the long-term prevention of biofilm formation, all current approaches have drawbacks in terms of their longevity and/or ability to be applied at the point-of-use on diverse surfaces instead of directly during manufacturing. In this Alliance project, a team of researchers from McMaster University will work closely with Suncor Energy to develop sprayable coatings that can adhere to a variety of surfaces to facilitate long-term anti-microbial and anti-biofilm activity over time periods ranging from a few days to several months, depending on the target application. By developing techniques to integrate bioactive formulations identified by Suncor for highly effective bacteria/biofilm deactivation into sprayable polymer and/or hydrogel-based precursor solutions thatcan form thin films upon drying, we aim to develop environmentally-friendly (and in some cases fully bio-based) coatings that can immobilize, stabilize, and control the release of the bioactive agents over time, facilitating surface sterilization relevant to use in agriculture (preventing plant disease to enhance crop yields), consumer products (preventing disease transmission via high-touch surfaces like countertops, door knobs, or transit rails), industrial equipment (maintaining long-term operation of fermentation reactors or oil pipelines), and other applications. The close collaboration between the Suncor and McMaster teams, including on-site work at McMaster by Suncor employees, will ensure an integrated project workflow ideal to collaboratively develop a line of sprayable anti-microbial coatings with health and economic benefits to Canada.

共同19岁的大流行和对新兴抗生素耐药细菌的关注度越来越多，已经开发出了新的方法，以使病原体在表面上越来越关键。在像生物医学植入物一样多样化的生物反应器到石油管道的多种多样的区域，它可以消除致密的生物膜（细菌和细胞外聚合物的组合）比杀死单一细菌更具挑战性，而现在所有（几乎很少）（几乎没有）（几乎没有）可用于生物纤维菌造型或具有非常有害环境有毒的构成有毒物质的产品。尽管某些工程表面表现出了长期预防生物膜形成的潜力，但所有当前的方法都有缺点，其寿命和/或能够在使用点上应用于不同表面而不是直接在制造过程中的能力。在这个联盟项目中，来自麦克马斯特大学的一组研究人员将与Suncor Energy紧密合作，以开发可喷涂的涂料，这些涂料可以粘附在各种表面，以促进长期的抗微生物和抗生物膜活动，范围从几天到几个月不等，根据目标应用程序。 By developing techniques to integrate bioactive formulations identified by Suncor for highly effective bacteria/biofilm deactivation into sprayable polymer and/or hydrogel-based precursor solutions thatcan form thin films upon drying, we aim to develop environmentally-friendly (and in some cases fully bio-based) coatings that can immobilize, stabilize, and control the release of the bioactive agents over time, facilitating surface与在农业中使用（预防植物性疾病提高农作物产量），消费产品（防止台面，门旋钮或过境轨道），工业设备（维持发酵反应堆或油管管道的长期运行）以及其他应用相关的灭菌。 Suncor和McMaster团队之间的密切合作，包括Suncor员工在McMaster的现场工作，将确保一个集成的项目工作流程理想，以合作开发一系列可喷涂的反微型涂料，对加拿大的健康和经济利益。