PRE-CLINICAL AND CLINICAL MULTIPURPOSE PREVENTION TECHNOLOGIES

临床前和临床多用途预防技术

• 批准号: 10924372
• 负责人: JIM TURPIN
• 金额: $ 2.49万
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2024-08-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10924372
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Anti-Infective Agents; Authorization documentation; Award; Characteristics; Clinical; Clinical Research; Contraceptive Agents; Contraceptive methods; Contracts; Development; Drug Combinations; Drug Delivery Systems; Effectiveness; Event; Experimental Designs; Funding; Goals; Government; Grant; HIV; Individual; Knowledge; Male Contraceptive Agents; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Pattern; Perception; Persons; Pharmaceutical Preparations; Pregnancy; Prevention; Property; Reproductive Health; Research; Safety; Services; Sexual Health; Sexually Transmitted Diseases; Technology; Woman; authority; biophysical properties; drug action; experience; insight; men; pre-clinical; pregnancy prevention; prevent; programs; skills; uptake

NICHD supports a broad range of contraceptive research, including efforts to develop male contraceptives and Multipurpose Prevention Technologies (MPTs). MPT products that prevent both pregnancy and sexually transmitted infections (STIs) would increase sexual and reproductive health options for both women and men. MPTs are composed of a combination of drugs that can target prevention of pregnancy, STIs and/or HIV, delivered using either an on-demand and event-driven or long-acting drug delivery system (DDS) with rheological/biophysical properties and product user perceptions (look, feel, effectiveness, safety and duration of action) that support user uptake (first use, subsequent use and habitual use). By combining prevention products for pregnancy and HIV or STI, the MPT may have a greater uptake and adherence than individual products. Key to the concept of MPTs is creation of DDS to support convenience of use, that not only are safe and deliver the drugs consistently but have durations of action relevant to the user needs. MPTs (contraceptive and non-contraceptive) may encompass a wide range of delivery durations and use patterns from on demand, event-driven or sustained/extended-release durations (months to years).

NICHD支持广泛的避孕研究，包括开发男性避孕药和多用途预防技术（MPT）的努力。 预防怀孕和性传播感染（性传播感染）的MPT产品（性传播感染）将增加男女的性健康和生殖健康选择。 MPT由可以针对怀孕，性传播感染和/或艾滋病毒的药物组合组成，这些药物使用按需和事件驱动或长效药物输送系统（DDS）以及流变学/生物物理学特性以及产品用户的看法以及支持用户的使用（效率，安全性，安全性和行动）的使用（以使用useptake和Teptake）的使用（以下用户）使用（以供使用和使用）使用（以供使用）使用（以uptake和Tectual（first）使用（后续使用），并以上的使用和习惯（以供使用）（以供使用）使用（以下方式）使用（以后使用）使用（以供使用）使用（以后使用）使用（以后使用）。通过结合预防妊娠和艾滋病毒或性传播疾病的预防产品，MPT可能比单个产品具有更大的摄取和依从性。 MPT概念的关键是创建DDS以支持使用的便利性，不仅安全，而且始终如一地提供药物，而且具有与用户需求相关的行动时间。 MPT（避孕药和非注重）可能包括广泛的交货时间，并使用按需，事件驱动或持续/扩展释放持续时间（几个月至几年）中的模式。