A Bioprinter System for Fabricating Advanced Biomaterials

用于制造先进生物材料的生物打印机系统

• 批准号: RTI-2021-00007
• 负责人: Frampton, John
• 金额: $ 10.92万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718211
• 关键词: Bioprinter; System; Fabricating; Advanced; Biomaterials

Bioprinting is an emerging technology that utilizes technical advancements in robotics and liquid handling for precise deposition of biological materials such as polymers and cells. The bioprinting industry is growing rapidly and there is an urgent need for training highly qualified personnel in this area and to update academic infrastructure accordingly. The requested equipment will directly support three research programs in the School of Biomedical Engineering at Dalhousie University focused on the design, fabrication and application of novel biomaterials. The equipment will also accelerate existing collaborations among researchers from four Faculties at Dalhousie University (Engineering, Medicine, Dentistry and Science) and help to initiate new collaborations with researchers across Canada developing cutting-edge biomaterials. The projects that this equipment will benefit include: (1) Engineering Scaffold-based and Scaffold-free 3D Cell Culture Microenvironments in the Frampton Lab; (2) Manufacture and Analysis of Lab-Grown Epidermal Tissues in the Frampton Lab; (3) Fabrication of Composite Fiber-Gel Soft Biomaterials in the Frampton Lab; (4) Rapid Liquid Printing of Blood-Brain Barrier Models in the Frampton Lab; (5) Simulating Mammalian-Microbe Interactions in the Mucosal Microenvironment in the Leung Lab; (6) Tracking Cell Fate in Heterogeneous Tumour Microenvironments in the Leung Lab; (7) Biomaterial Design for Endodontic Regeneration in the Leung Lab; (8) Manufacture and Analysis of Airway Microtissues in the Maksym Lab; and (9) Investigating Structure-Function Relationships in Airway Rings in the Maksym Lab. A precision bioprinter system will attract highly qualified personnel from physics, materials science, engineering, and the life sciences who wish to utilize bioprinting to enhance their research. Trainees from these disciplines will have the ability to rapidly develop new materials with complex geometries and compositions, which cannot be achieved with any of the existing equipment for liquid handling and rapid prototyping at Dalhousie University. The ease of use and versatility of the requested bioprinter system will allow existing resources and expertise at Dalhousie University to be best-utilized to see that the various projects listed above reach a state of research- and industry-readiness. It will also serve as an additional resource to enhance the capabilities of existing infrastructure targeted at fabrication and rapid prototyping of non-living structures.

Bioprinting是一种新兴技术，它利用机器人技术和液体处理中的技术进步来精确沉积聚合物和细胞等生物材料。生物打印行业正在迅速发展，迫切需要在该领域培训高素质的人员并相应地更新学术基础设施。所请求的设备将直接支持达尔豪斯大学生物医学工程学院的三个研究计划，重点是新型生物材料的设计，制造和应用。该设备还将加快达尔豪斯大学四个学院（工程，医学，牙科和科学）的研究人员之间的现有合作，并有助于与加拿大开发尖端生物材料的研究人员进行新的合作。该设备将受益的项目包括：（1）Frampton Lab中的基于工程脚手架和无脚手架的3D细胞培养微环境； （2）弗兰普顿实验室中实验室生长的表皮组织的制造和分析； （3）在Frampton Lab中制造复合纤维 - 柔软的生物材料； （4）弗兰普顿实验室中血脑屏障模型的快速液体印刷； （5）模拟Leung实验室中粘膜微环境中的哺乳动物 - 微生物相互作用； （6）在Leung实验室中的异质肿瘤微环境中跟踪细胞命运； （7）Leung实验室中牙髓再生的生物材料设计； （8）Maksym实验室中气道微动物的制造和分析； （9）调查Maksym实验室气道环中的结构 - 功能关系。精确的生物生产系统将吸引来自物理学，材料科学，工程学以及希望利用生物打印来增强其研究的生命科学的高素质人员。来自这些学科的学员将能够快速开发具有复杂几何形状和构图的新材料，这在达尔豪西大学的任何现有设备上都无法实现。所请求的生物生产系统的易用性和多功能性将使Dalhousie University的现有资源和专业知识得到最好的利用，以确保上面列出的各种项目达到了研究和行业的精通状况。它还将作为增强针对制造和快速原型非生存结构的现有基础设施能力的附加资源。