Optical theragnostics: developing dedicated instruments to concurrently see and treat lesions

光学治疗诊断学：开发专用仪器来同时观察和治疗病变

• 批准号: RGPIN-2018-06151
• 负责人: Boudoux, Caroline
• 金额: $ 2.84万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=713797
• 关键词: Optical; theragnostics; developing; dedicated; instruments

The past decades have witnessed a rapid evolution of optical technologies applied to medical imaging and laser surgery. This proposal brings together the fields of biophotonics, lasers and fiber optics towards the development of new devices enabling the integration of imaging and therapy within a single fiber optics probe for simultaneous diagnosis and treatment of cancers: a field called theragnostics. Since its first occurrence in the scientific literature, the imaging modality called optical coherence tomography (OCT) has become the standard of diagnosis for ophthalmic diseases and is finding many new applications in health sciences such as the detection of cardiovascular and precancerous lesions. The rapidly growing interest in OCT stems from its unique ability to visualize tissues non-invasively with a resolution of 10 microns and at depths of up to 3mm, which translates into the potential of skipping the biopsy stage for on-the-spot diagnosis. The core technologies behind OCT (i.e. lasers and fiber optics) allow bridging the current gap existing between diagnosis and treatment. Using my laboratory's combined expertise of laser--tissue interactions, fiber optics, fiber laser design, and optical image processing, I propose to set the cornerstone towards single fiber OCT-monitored laser tissue coagulation and ablation. In other words, I propose to develop a see-and-treat tool based on novel fiber optics and lasers. Laser delivery to inner organs is limited by the type of optics being used. For coherent imaging, such as OCT, single mode fibers are used, while for therapy, multimode fibers are required to support high power densities. I plan to leverage from the technology my laboratory developed, the double clad fiber (DCF) coupler, to create the perfect instrument for concurrent OCT imaging, through the core of the DCF, and laser therapy, through the surrounding inner cladding of the same DCF. In addition to creating the instrument, image-processing tools will be refined to automate the laser therapy process. As energy is converted to heat at the nanosecond regime (or faster), I will use properties of OCT images known as speckle to automatically dictate when treatment should stop, thus avoiding key anatomical structures faster than the eye can see. This program has the potential to train several engineering students in a multidisciplinary environment, and to introduce them to the translation of the techniques to the clinical suite and to industrial partners. My trainees evolve in a gender-balanced, multi-cultural environment. They rapidly become citizen of the international community of biomedical optics scientists through publications in top-tier journals, participation to international conferences and collaborations. As a group, we focus on improving the well-being of Canadians though technology transfer to industry and the development of innovative theragnostic techniques.

过去几十年来，光学技术的快速发展应用于医学成像和激光手术。该提案汇集了生物素，激光和光纤领域，以开发新设备，从而使成像和治疗在单个光纤光学探针中的整合，以同时诊断和治疗癌症：一种称为theragnostics的领域。 自从科学文献中首次出现以来，称为光学相干断层扫描（OCT）的成像方式已成为眼科疾病的诊断标准，并在健康科学中发现了许多新应用，例如发现心血管疾病和前癌性病变。对OCT的迅速增长的兴趣源于其独特的能力，可以通过10微米的分辨率和最高3mm的深度可视化组织，这转化为跳过活检阶段进行现场诊断的潜力。 OCT背后的核心技术（即激光器和光纤元件）允许弥合诊断和治疗之间存在的当前差距。使用我的实验室的激光相互作用 - 组织相互作用，光纤，纤维激光设计和光学图像处理，我建议将基石设置为单个纤维OctIce octed的激光组织凝结和消融。换句话说，我建议根据新颖的光纤和激光开发一种可见的工具。 激光输送到内脏器官受到使用的光学元件类型的限制。对于相干成像，例如OCT，使用单模纤维，而对于治疗，需要多模纤维来支撑高功率密度。 我计划从我的实验室开发的技术中利用双层纤维（DCF）耦合器，以通过DCF的核心和激光治疗创造出完美的同时进行OCT成像的工具，并通过同一DCF的周围内部覆层。除了创建仪器外，图像处理工具还将被改进以自动化激光治疗过程。由于能量在纳秒级（或更快）下转换为热量，因此我将使用称为Speckle的OCT图像的属性自动决定应何时停止治疗，从而避免键的解剖结构比眼睛更快。 该计划有可能在多学科环境中培训几名工程专业的学生，​​并将其介绍给将技术转换为临床套件和工业合作伙伴。我的学员在性别平衡的多元文化环境中发展。他们通过顶级期刊的出版物，参加国际会议和合作的出版物，迅速成为国际生物医学光学科学家国际社会的公民。作为一个小组，我们专注于通过技术转移到工业的发展以及创新的Theragnostic技术的发展来改善加拿大人的福祉。