Organic Chemistry

有机化学

• 批准号: 1000233058-2019
• 负责人: Rousseaux, Sophie
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696087
• 关键词: Organic; Chemistry

Over the last century, impressive developments in transition metal-catalysis have enabled the production of molecules in our everyday lives, including medicines, plastics, and food. Our needs are now shifting towards the development of more efficient processes for their preparation, from both an environmental and economic point of view. Dr. Sophie Rousseaux leads an internationally recognized research program focused on using earth-abundant and inexpensive nickel catalysts to efficiently prepare value-added products from abundant feedstocks. The proposed research program aims to explore the reactivity of new redox-active alcohol derivatives in Ni-catalyzed cross-couplings with a focus on the synthesis of pharmaceutically-relevant molecules.

在上个世纪，过渡金属催化领域取得了令人瞩目的发展，使得我们日常生活中的分子生产成为可能，包括药物、塑料和食品。从环境和经济的角度来看，我们的需求现在转向开发更有效的制备工艺。 Sophie Rousseau 博士领导了一项国际公认的研究项目，重点是利用地球上储量丰富且廉价的镍催化剂，从丰富的原料中高效制备增值产品。拟议的研究计划旨在探索镍催化交叉偶联中新型氧化还原活性醇衍生物的反应性，重点是药物相关分子的合成。