Canada Research Chair in Structural Biology

加拿大结构生物学研究主席

• 批准号: CRC-2016-00259
• 负责人: Stetefeld, Jörg
• 金额: $ 14.57万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694248
• 关键词: Canada; Research; Chair; Structural; Biology

A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.

对（i）与人类疾病相关的动态高阶信号传导复合物的形成的细胞外蛋白的结构特性关系的分子理解以及（ii）建立来自极端粒细胞生殖的独特的S层组件对于在生物医学和生物技术学领域中基于结构的应用的发展至关重要。蛋白质在细胞通信和细胞基质信号传导中的结构动力学的探索非常重要。在第二大道的研究中，我们正在利用S层盘绕线圈来设计行业适用的监视和补救工具。基于盘绕螺旋纳米管的独特特征的结构引导应用程序的开发是应用程序驱动研究的一种新方法。 我们将继续应用并进一步制定一项综合研究计划，结合了高分辨率结构生物学技术以及各种生物物理和功能方法。