Maud Menten New Principal Investigator Prize in Genetics: Decoding gene & genome-regulatory functions of the RNA gene CISTR-ACT

Maud Menten 遗传学新首席研究员奖：解码基因

• 批准号: 433196
• 负责人: Maass Philipp
• 金额: $ 2.19万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433196&lang=en
• 关键词: Crispr Live-Cell Imaging; Epigenomics; Functional Genomics; Genome Organization; Hi-C; Inter-Chromosomal Contacts; Long Non-Coding Rnas; Novel Disease Mechanisms; Rare Disease; Rna Genes

Three-dimensional genome organization in mammalian cells is important for gene regulation. Rewiring of gene-regulatory mechanisms can cause rare disease and cancer. Whilst interactions between genes and their regulators on the same chromosome are well cha

哺乳动物细胞中的三维基因组组织对于基因调控非常重要。基因调节机制的重新连接可能导致罕见疾病和癌症。虽然同一染色体上的基因与其调节因子之间的相互作用很容易发生变化。