Photonic Biosensors for Point of Care Diagnostics, Monitoring and Screening

用于护理点诊断、监测和筛查的光子生物传感器

• 批准号: RGPIN-2016-06559
• 负责人: Aitchison, JStewart
• 金额: $ 2.99万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=688335
• 关键词: Photonic; Biosensors; Point; Care; Diagnostics

The combination of photonics and microfluidics provides an opportunity to develop portable medical diagnostics, screening and monitoring systems. These high quality, point of care testing systems enable health care technologies to be taken directly to the patient. Such systems have particularly important applications in developing countries where there is often a lack of access to state of the art medical diagnostic facilities. However there is also potential for their use in developed countries, which are struggling with spiraling health costs and where low cost portable diagnostics can provide more rapid results which leads to more effective care. In addition point of care systems open up the possibility of personalized treatment whereby the effect of medications can be monitored in real time and effective dosages optimized on an individualized patient basis.******To make point of care testing a reality, there is a need to develop improved, multi-modal systems which are capable of measuring simultaneously more than a single parameter. This discovery grant application outlines a program of work that will enable a) the development of multi-modal sensing methodologies and b) the development of on-chip lasers and spectrometers. It is the combination of these research themes which will enable the development of rugged and robust point of care systems.******Trainees engaged on the project will have the opportunity to work on a number of multi-disciplinary projects aimed at developing tests such as optical enzyme-linked immunosorbent assays (ELISA) and surface plasmon molecular sensors. The research program will also focus on integrating sample preparation steps with the photonic sensors to produce a cartridge-based approach to integrating a particular test. In parallel this discovery grant will support work on the development of a vertical approach to monolithically integrating III-V semiconductor components on a single chip to produce the spectrometers and lasers required to enable the portable systems described. Trainees will have the opportunity to interact with experts in nanotechnology, biomedical engineering and medical diagnostics.******The combination of integrated optics and micro-fluidics is set to enable portable medical diagnostics, screening and monitoring systems. In the longer term, advance laser sources and integrated spectrometers will deliver a completely non-invasive approach to blood testing which does not require a finger prick sized sample. This will make systems more user friendly and compatible with the burgeoning wearable health-related technology sector.

光子学和微流体的组合为开发便携式医疗诊断，筛查和监测系统提供了机会。这些高质量的护理点测试系统使医疗保健技术能够直接带给患者。这种系统在发展中国家通常缺乏进入状态的医学诊断设施的发展中国家中特别重要的应用。但是，它们在发达国家中的使用也有潜力，他们在螺旋式的健康成本中挣扎，而低成本便携式诊断可以提供更快的结果，从而导致更有效的护理。 此外，护理系统开辟了个性化治疗的可能性，可以实时监测药物的影响，并根据个性化患者进行优化的有效剂量。是需要开发改进的多模式系统，这些系统能够同时衡量的是单个参数。该发现赠款应用程序概述了一项工作计划，该计划将使a）开发多模式传感方法和b）芯片激光器和光谱仪的开发。这些研究主题的结合将使崎and的护理系统的开发发展。******从事该项目的受训者将有机会从事许多旨在发展的多学科项目诸如光学酶联免疫吸附测定（ELISA）和表面等离子体分子传感器之类的测试。该研究计划还将集中于将样品制备步骤与光子传感器集成，以产生基于墨盒的方法来集成特定测试。同时，该发现赠款将支持开发垂直方法的工作，以单层次将III-V半导体组件整合在单个芯片上，以生成启用所描述的便携式系统所需的光谱仪和激光器。学员将有机会与纳米技术，生物医学工程和医学诊断方面的专家进行互动。从长远来看，前进的激光源和集成光谱仪将提供一种完全无创的血液测试方法，而该方法不需要手指刺穿大小的样品。这将使系统更加用户友好，并且与新兴可穿戴健康相关的技术领域兼容。