Photonic Biosensors for Point of Care Diagnostics, Monitoring and Screening

用于护理点诊断、监测和筛查的光子生物传感器

• 批准号: RGPIN-2016-06559
• 负责人: Aitchison, JStewart
• 金额: $ 2.99万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616387
• 关键词: Photonic; Biosensors; Point; Care; Diagnostics

The combination of photonics and microfluidics provides an opportunity to develop portable medical diagnostics, screening and monitoring systems. These high quality, point of care testing systems enable health care technologies to be taken directly to the patient. Such systems have particularly important applications in developing countries where there is often a lack of access to state of the art medical diagnostic facilities. However there is also potential for their use in developed countries, which are struggling with spiraling health costs and where low cost portable diagnostics can provide more rapid results which leads to more effective care. In addition point of care systems open up the possibility of personalized treatment whereby the effect of medications can be monitored in real time and effective dosages optimized on an individualized patient basis. To make point of care testing a reality, there is a need to develop improved, multi-modal systems which are capable of measuring simultaneously more than a single parameter. This discovery grant application outlines a program of work that will enable a) the development of multi-modal sensing methodologies and b) the development of on-chip lasers and spectrometers. It is the combination of these research themes which will enable the development of rugged and robust point of care systems. Trainees engaged on the project will have the opportunity to work on a number of multi-disciplinary projects aimed at developing tests such as optical enzyme-linked immunosorbent assays (ELISA) and surface plasmon molecular sensors. The research program will also focus on integrating sample preparation steps with the photonic sensors to produce a cartridge-based approach to integrating a particular test. In parallel this discovery grant will support work on the development of a vertical approach to monolithically integrating III-V semiconductor components on a single chip to produce the spectrometers and lasers required to enable the portable systems described. Trainees will have the opportunity to interact with experts in nanotechnology, biomedical engineering and medical diagnostics. The combination of integrated optics and micro-fluidics is set to enable portable medical diagnostics, screening and monitoring systems. In the longer term, advance laser sources and integrated spectrometers will deliver a completely non-invasive approach to blood testing which does not require a finger prick sized sample. This will make systems more user friendly and compatible with the burgeoning wearable health-related technology sector.

光子学和微流体学的结合为开发便携式医疗诊断、筛查和监测系统提供了机会。这些高质量的护理点测试系统使医疗保健技术能够直接应用于患者。这种系统在发展中国家具有特别重要的应用，因为这些国家经常缺乏最先进的医疗诊断设施。然而，它们在发达国家也有使用潜力，这些国家正在努力应对不断上升的医疗成本，而低成本的便携式诊断可以提供更快速的结果，从而带来更有效的护理。此外，护理点系统还开辟了个性化治疗的可能性，可以实时监测药物的效果，并根据个体患者优化有效剂量。 为了使即时测试成为现实，需要开发改进的多模式系统，该系统能够同时测量多个单一参数。该发现拨款申请概述了一项工作计划，该计划将促进 a) 多模态传感方法的开发和 b) 片上激光器和光谱仪的开发。这些研究主题的结合将有助于开发坚固耐用的护理点系统。 参与该项目的学员将有机会参与许多旨在开发光学酶联免疫吸附测定（ELISA）和表面等离子体分子传感器等测试的多学科项目。该研究计划还将侧重于将样品制备步骤与光子传感器集成，以产生基于盒的方法来集成特定测试。与此同时，这一发现拨款将支持开发一种垂直方法，将 III-V 族半导体元件单片集成在单个芯片上，以生产实现所述便携式系统所需的光谱仪和激光器。学员将有机会与纳米技术、生物医学工程和医学诊断方面的专家互动。 集成光学和微流体技术的结合将实现便携式医疗诊断、筛查和监测系统。从长远来看，先进的激光源和集成光谱仪将提供一种完全非侵入性的血液检测方法，不需要刺破手指大小的样本。这将使系统更加用户友好，并与新兴的可穿戴健康相关技术领域兼容。