Optical Coherence Tomography, Molecular Guided Imaging, and Surgical Navigation for targeted and controlled Laser Ablation

用于定向和受控激光消融的光学相干断层扫描、分子引导成像和手术导航

• 批准号: RGPIN-2019-06598
• 负责人: Yang, Victor
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=682663
• 关键词: Optical; Coherence; Tomography; Molecular; Guided

This proposal from PI Yang continues work in the development of image-guided techniques for the neurosurgical operating room (OR) and beyond.***Objectives***Our broad goals include:***1) Development of novel imaging methods for tissue detection and delineation***2) Fusion of imaging methods for display and surgical navigation***3) Image-guidance and fusion for therapeutic targeting***4) Imaging methods for monitoring of therapeutic effects***Specific aims are:***1) Continued work on structural and vascular (Speckle Variance and Doppler Optical Coherence Tomography; SV/D-OCT) methods for the detection and delineation of vasculature, with adoption of these methods for functional imaging***2) Continued development of elastography methods for OCT for the delineation of various tissue types, including brain tissue structures and healthy vs. diseased tissues***3) Continued development of molecular fluorescence techniques, with focus on the adoption of quantitative, depth resolved, and 3D methods***4) Fusion of data for OCT and fluorescence with current MVIGS system***5) Optimization of information workflow to prevent cognitive overload***6) Translation of navigation information to robot-mounted ablation lasers for targeted and controlled ablation of structures with OCT control***Technological foci, methods, work to date***Core technologies previously established in by the BBL will continue to be developed, specifically:***1) OCT: An infrared based interferometric method with 10 micron lateral resolution, and depth imaging of up to 3mm. We have continued to develop methods for structural and vascular imaging (SV/D-OCT), as well as OCE, and will continue to translate these to a surgical setting.***2) Molecular guided fluorescence imaging: This method uses specific molecular fluorophores to allow imaging of targets. We have developed a temporally controlled biophotonics operating room allowing for real-time imaging without disruption of workflow, and are working to establish quantitative methods.***3) Machine Vision Image Guided Surgery (MVIGS): We have developed a navigation system that combines structured light with presurgical imaging for tool localization. We aim to continue to look at developing methods for the integration of other imaging modalities with our current navigation system for optimized workflow.***4) Guided Laser Ablation: We have developed methods for OCT-controlled laser ablation using fiber lasers in a size-envelope similar to that of a laptop. We are currently working to characterize these systems, and to use MVIGS with robotics for macroscopic guidance, and OCT and fluorescence for micro-guidance.***Impact***The above research is of particular importance to allow for the translation of these novel technologies into the OR. We aim to bring these technologies into the OR with workflow considerations in mind, and to expand their use beyond the neurosurgical operating room to other areas of surgery and medicine, with opportunity for IP generation and job creation.**

PI Yang 的这项提案继续致力于开发神经外科手术室 (OR) 及其他领域的图像引导技术。***目标***我们的总体目标包括：***1) 开发新型组织成像方法检测和描绘***2) 用于显示和手术导航的成像方法融合***3) 用于治疗靶向的图像引导和融合***4) 用于监测治疗效果的成像方法***具体目标是：* **1) 继续研究结构和血管（散斑方差）和多普勒光学相干断层扫描；SV/D-OCT）用于检测和描绘脉管系统的方法，并采用这些方法进行功能成像***2）持续开发用于描绘各种组织类型的 OCT 弹性成像方法，包括脑组织结构以及健康组织与患病组织***3) 分子荧光技术的持续发展，重点是采用定量、深度分辨和 3D 方法***4) 将 OCT 和荧光数据与电流融合MVIGS 系统***5) 优化信息工作流程，防止认知超载***6) 将导航信息翻译至机器人安装的消融激光器，通过 OCT 控制对结构进行定向和受控消融***技术重点、方法和工作日期*** BBL 先前建立的核心技术将继续发展，具体为：***1) OCT：一种基于红外的干涉测量方法，横向分辨率为 10 微米，深度成像可达 3 毫米。我们继续开发结构和血管成像 (SV/D-OCT) 以及 OCE 方法，并将继续将这些方法转化为手术环境。***2) 分子引导荧光成像：该方法使用特定的分子荧光团以允许目标成像。我们开发了一个时间控制的生物光子手术室，可以在不中断工作流程的情况下进行实时成像，并正在努力建立定量方法。***3) 机器视觉图像引导手术 (MVIGS)：我们开发了一种导航系统，结合了结构光与术前成像用于工具定位。我们的目标是继续研究开发方法，将其他成像模式与我们当前的导航系统集成，以优化工作流程。***4) 引导激光烧蚀：我们已经开发了使用一定尺寸的光纤激光器进行 OCT 控制的激光烧蚀的方法。 - 类似于笔记本电脑的信封。我们目前正在努力表征这些系统，并使用 MVIGS 与机器人技术进行宏观引导，并使用 OCT 和荧光进行微观引导。***影响***上述研究对于翻译这些小说特别重要技术进入手术室。我们的目标是在考虑工作流程的情况下将这些技术引入手术室，并将其用途从神经外科手术室扩展到外科和医学的其他领域，并为知识产权生成和创造就业机会提供机会。**