Optical Coherence Tomography, Molecular Guided Imaging, and Surgical Navigation for targeted and controlled Laser Ablation

用于定向和受控激光消融的光学相干断层扫描、分子引导成像和手术导航

• 批准号: RGPIN-2019-06598
• 负责人: Yang, Victor
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=682663
• 关键词: Optical; Coherence; Tomography; Molecular; Guided

This proposal from PI Yang continues work in the development of image-guided techniques for the neurosurgical operating room (OR) and beyond.***Objectives***Our broad goals include:***1) Development of novel imaging methods for tissue detection and delineation***2) Fusion of imaging methods for display and surgical navigation***3) Image-guidance and fusion for therapeutic targeting***4) Imaging methods for monitoring of therapeutic effects***Specific aims are:***1) Continued work on structural and vascular (Speckle Variance and Doppler Optical Coherence Tomography; SV/D-OCT) methods for the detection and delineation of vasculature, with adoption of these methods for functional imaging***2) Continued development of elastography methods for OCT for the delineation of various tissue types, including brain tissue structures and healthy vs. diseased tissues***3) Continued development of molecular fluorescence techniques, with focus on the adoption of quantitative, depth resolved, and 3D methods***4) Fusion of data for OCT and fluorescence with current MVIGS system***5) Optimization of information workflow to prevent cognitive overload***6) Translation of navigation information to robot-mounted ablation lasers for targeted and controlled ablation of structures with OCT control***Technological foci, methods, work to date***Core technologies previously established in by the BBL will continue to be developed, specifically:***1) OCT: An infrared based interferometric method with 10 micron lateral resolution, and depth imaging of up to 3mm. We have continued to develop methods for structural and vascular imaging (SV/D-OCT), as well as OCE, and will continue to translate these to a surgical setting.***2) Molecular guided fluorescence imaging: This method uses specific molecular fluorophores to allow imaging of targets. We have developed a temporally controlled biophotonics operating room allowing for real-time imaging without disruption of workflow, and are working to establish quantitative methods.***3) Machine Vision Image Guided Surgery (MVIGS): We have developed a navigation system that combines structured light with presurgical imaging for tool localization. We aim to continue to look at developing methods for the integration of other imaging modalities with our current navigation system for optimized workflow.***4) Guided Laser Ablation: We have developed methods for OCT-controlled laser ablation using fiber lasers in a size-envelope similar to that of a laptop. We are currently working to characterize these systems, and to use MVIGS with robotics for macroscopic guidance, and OCT and fluorescence for micro-guidance.***Impact***The above research is of particular importance to allow for the translation of these novel technologies into the OR. We aim to bring these technologies into the OR with workflow considerations in mind, and to expand their use beyond the neurosurgical operating room to other areas of surgery and medicine, with opportunity for IP generation and job creation.**

Pi Yang的这一提议继续在开发神经外科手术室的图像引导技术（OR）及以后的图像引导技术中。监测治疗效果***具体目的是：*** 1）在结构和血管（斑点方差和多普勒光学相干性层析成像； SV/D-OCT）方面继续进行脉管系统的检测和描述，并采用这些方法的多种脑组织，以促进精明的方法，以进行精明的方法，以进行十月的脑组织，以进行精明的方法。与患病组织*** 3）持续开发分子荧光技术，重点是采用定量，深度解决和3D方法*** 4）oct和当前MVIGS系统的数据融合*** 5） OCT控制***技术焦点，方法，迄今为止的工作***先前由BBL建立的核心技术将继续开发，特别是：*** 1）OCT：一种基于红外的干涉方法，具有10微米横向分辨率，并且深度成像高达3mm。我们继续开发用于结构和血管成像（SV/D-OCT）以及OCE的方法，并将继续将其转化为手术环境。*** 2）分子引导荧光成像：此方法使用特定的分子荧光团允许目标成像。我们已经开发了一个由时间控制的生物探测器手术室，可实时成像而不会破坏工作流程，并正在努力建立定量方法。*** 3）机器视觉图像指导手术（MVIGS）：我们开发了一种将结构性光与工具定位的结构光结合在一起的导航系统。我们旨在继续研究开发其他成像方式与当前导航系统进行优化工作流程的方法。*** 4）引导激光消融：我们开发了使用与尺寸 - 型号的尺寸 - 型号类似于载体的尺寸的光纤激光器的OCT控制激光消融的方法。我们目前正在努力表征这些系统，并使用具有机器人技术的MVIG进行宏观指导，而OCT和荧光进行微型引导。我们的目标是考虑到工作流程的考虑，将这些技术带入OR，并将其用途扩展到神经外科手术室以外的手术和医学领域，并提供IP生成和创造就业机会的机会。**