Photodynamic therapy of non-melanoma skin cancers - development of a comprehensive image-guided planning system for personalized treatment

非黑色素瘤皮肤癌的光动力疗法 - 开发用于个性化治疗的综合图像引导规划系统

• 批准号: 508408-2017
• 负责人: Yang, Victor
• 金额: $ 6.7万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621904
• 关键词: Photodynamic; therapy; non; melanoma; skin

In Radiotherapy, dosimetry and treatment planning are highly advanced for ionizing radiation.Radiation dose is accurately defined and the relationship between it andclinical response is well understood. For photodynamic therapy (PDT), the definition of PDTdose is unclear and how it correlates with clinical response has yet to be precisely defined.Present-day clinical protocols for PDT of non-melenoma skin cancer (NMSC) are relativelystraight-forward: a photosensitizer is administered, a period of time elapses before shininglight and then light with a specific fluence rate illuminates the patient. The same protocol isapplied to an entire patient population and as a result, PDT of NMSC is conducted withoutdetailed customized planning that takes into account patient to patient variability as practicedin radiotherapy. Our research goal is to work on in vivo measurement of optical properties andfunctional parameters such as oxygen levels together with measuring the temporal andspatial photosensitizer concentration uptake. With these quantitative metrics, the hope is thatwe will be able to model and predict the response of individual patients to PDT.. Betterdosimetry will advance the development and utilization of PDT similar to radiation therapywhere the field is very quantitative and evidence-based. Ultimately patient-specific planning ofPDT treatment will increase NMSC clinical outcomes.

在放射治疗中，电离辐射的剂量测定和治疗计划非常先进。辐射剂量被准确定义，并且它与临床反应之间的关系很好理解。对于光动力疗法 (PDT)，PDT 剂量的定义尚不清楚，其与临床反应的关系也尚未明确定义。目前非黑素瘤皮肤癌 (NMSC) PDT 的临床方案相对简单：光敏剂施用后，在照射光之前经过一段时间，然后具有特定通量率的光照射患者。相同的方案适用于整个患者群体，因此，NMSC 的 PDT 是在没有详细的定制计划的情况下进行的，该计划考虑了放射治疗中患者与患者之间的差异。我们的研究目标是致力于光学特性和功能参数（例如氧含量）的体内测量，以及测量时间和空间光敏剂浓度的摄取。有了这些定量指标，我们希望能够模拟和预测个体患者对 PDT 的反应。更好的剂量测定将促进 PDT 的开发和利用，类似于放射治疗，该领域是非常定量和基于证据的。最终，针对患者的 PDT 治疗计划将提高 NMSC 的临床结果。