Caractérisation des polyamines de la laitance de hareng et validation des propriétés bioactives sur culture cellulaire

哈伦浮层多胺的表征和细胞培养物生物活性物质的验证

• 批准号: 530893-2018
• 负责人: Blier, Pierre
• 金额: $ 1.23万
• 依托单位: Université du Québec à Rimouski
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=675814
• 关键词: Caract; risation; des; polyamines; de

The company Ocean NutraSciences developed a process to hydrolyses and extract active bio-ingredients from a waste product of fishery industry: herring milt. These ingredients are potentially rich in polyamines which have been shown to be active for heart protection and aging prevention in mammals, as well as for stress management in plants. There are therefore new market opportunities for herring milt hydrolysates. These implementations of the value of the products might not only help to develop a new industry, but also to fix an environmental problem by giving value to waste product. Even if these hydrolysates are already sold, new and solid scientific allegations will definitely give opportunities to expand the market. We are therefore planning to 1) Quantify the polyamins content of the three ingredients produced by ONS from herring milt hydrolysis and 2) Measure on specific health targets (cardio-vascular protection and aging process), different acknowledge biochemical and molecular markers on cellular models. We will particularly focus (but not exclusively) on oxidative stress and aging process. These analyses will be performed for two ingredients provided by ONS (the easiest one to produce and the one with highest content of polyamines). Documenting the biological activity of ONS's ingredients will definitely add value and allow new market development. We will also 3) Estimate the impact of the same two ingredients on stress managements in a model plant "arabidopsis". The plant will be exposed to osmotic and hydric stress. Organic Ocean expect to develop a niche market product for horticulture and agriculture industry to prevent stress impact, by providing ingredients that have been proven to attenuate the stress response.

Ocean NutraSciences 公司开发了一种从渔业废品鲱鱼鱼白中水解并提取活性生物成分的工艺。这些成分可能富含多胺，这些多胺已被证明对哺乳动物的心脏保护和预防衰老以及植物的应激管理具有活性。因此，鲱鱼鱼白水解物存在新的市场机会。这些产品价值的实现不仅有助于发展新产业，而且还可以通过赋予废品价值来解决环境问题。即使这些水解产物已经售出，新的、可靠的科学主张也肯定会带来扩大市场的机会。因此，我们计划 1) 量化 ONS 从鲱鱼精水解中产生的三种成分的多胺含量，2) 测量特定的健康目标（心血管保护和衰老过程），以及细胞模型上不同的生化和分子标记。我们将特别关注（但不限于）氧化应激和衰老过程。这些分析将针对 ONS 提供的两种成分（最容易生产的一种和多胺含量最高的一种）进行。记录 ONS 成分的生物活性肯定会增加价值并促进新的市场开发。我们还将 3) 估计相同的两种成分对模型植物“拟南芥”的应激管理的影响。植物将面临渗透压和水分胁迫。 Organic Ocean 希望通过提供已被证明可以减轻应激反应的成分，为园艺和农业开发一种利基市场产品，以防止应激影响。