Urgent Replacement Glovebox For Innovative Main Group Catalysis

紧急更换手套箱以实现创新的主族催化

• 批准号: RTI-2019-00004
• 负责人: Speed, Alexander
• 金额: $ 5.41万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665696
• 关键词: Urgent; Replacement; Glovebox; Innovative; Main

We are requesting funding for a urgent replacement of our group's double glovebox. The Speed group develops catalysts and reagents for organic synthesis using principles from main group chemistry. Over the past three years, we have emerged as one of the world's leading groups in asymmetric main-group catalysis. We have shown that diazaphospholenes can be used to prepare chiral amines by catalytic reduction. Chiral amines are vital components of many biologically active molecules. We have developed catalysts that can reduce imines to amines in the presence of many other reactive functional groups, allowing access to amines that are not readily prepared using existing catalysts. We are also studying the chemical functionalization of sulfur hexafluoride, to develop mild tools to incorporate the pentafluorosulfanyl group into complex molecules at a late stage in a synthesis. While medicinal chemists anticipate that the pentafluorosulfanyl group may impart unique properties to molecules, exploration of this group has been very limited because of the absence of methods to incorporate the pentafluorosulfanyl group under mild conditions. A breakthrough in this project will open up exploration of the properties of the pentafluorosulfanyl group in a wide variety of molecules. Our work is made possible by using a glovebox to synthesize and screen air sensitive catalysts and reagents. Our current glovebox, which was a surplus item within Dalhousie's Chemistry Department when I started, has enabled our research program. Unfortunately this older model glovebox is suffering from many technical problems that have led to significant and continued downtime and the generation of false-negative results due to the repeated compromise of sensitive reagents. A modern replacement glovebox will allow the Speed group to continue exploring main group chemistry as applied to organic synthesis with the knowledge that the chemistry is being conducted in an atmosphere that is free of contaminants that will interfere with the chemistry.

我们要求紧急替换我们小组的双重手套箱的资金。速度组使用主要组化学原理开发有机合成的催化剂和试剂。在过去的三年中，我们已经成为世界上不对称主要组催化中的领先群体之一。我们已经表明，氮杂磷脂可用于通过催化还原来制备手性胺。手性胺是许多生物活性分子的重要成分。我们已经开发了催化剂，可以在许多其他反应性官能团存在下将胺的催化剂减少到胺上，从而可以使用现有催化剂来访问不容易制备的胺。我们还研究了硫六氟化硫的化学功能化，以开发温和的工具，以在合成中的后期将五氟磺酰基群掺入复杂分子中。尽管药物化学家预计，五氟磺扬酰基可能会赋予分子独特的特性，但由于没有方法在轻度条件下掺入五氟乙烯基群的方法，因此对这一组的探索非常有限。该项目的突破将打开对多种分子中五氟磺酰基的性质的探索。通过使用手套箱合成和筛选空气敏感的催化剂和试剂，我们的工作成为可能。当我开始时，我们当前的手套箱是Dalhousie化学部门中的剩余物品，已经实现了我们的研究计划。不幸的是，由于敏感试剂的反复妥协，这种较旧的模型手套箱遭受了许多技术问题，导致了大量和持续的停机以及虚假阴性结果的产生。现代的替换手套箱将使速度组能够继续探索用于有机合成的主要组化学，并知道该化学是在不含污染物的大气中进行的，这种污染物会干扰化学。